Floxed Targeted Mouse Strain for Use in Conditional Deletion of the Irf8 Gene

IRF8, a member of interferon regulatory factor (IRF) family of transcription factors is a novel intrinsic transcriptional inhibitor of TH17-cell differentiation. TH17-cells are believed to be involved in the pathogenesis of various autoimmune/inflammatory diseases.
These materials could be used to help define patterns of gene expression important for the development and function of cells including possible contributions to understanding: normal immune responses, inflammatory conditions, autoimmunity and anti-viral responses.IC: NIAIDNIH Ref. No.: E-062-2012-0Advantages:  Mice with established germ line transmission for use in conditional deletion of the IRF8 gene in any cellt typeApplications: Target identification in B and T cell deficiency, macrophage defects and hematopoiesisA tool for investigating IRF8 mediated issues associated with inflammation and autoimmunityInvestigative tool for development of potential therapeutics for lymphoma and Human Chronic Myeloid LeukemiaProvider Technology ID: 3383Updated On: Aug 27, 2019Date Published: Tuesday, August 27, 2019Lead Inventor: Inventor IC: NIAIDLPM FIrst Name: ChristopherLPM Last Name: KornakLPM Address: BG 5601FL RM 6D28 MSC 9804
5601 FISHERS LNLPM City: BethesdaLPM Zip: 20892-9804Inv Is lead: LPM State: MDLPM Phone: [phone]LPM Email: [e-mail] Suffix: J.D.LPM Organization: NIH Office of Technology Transfer...

Source: NIH OTT Licensing Opportunities - August 27, 2019 Category: Research Authors: ajoyprabhu3 Source Type: research