Serum amyloid P and a DC-SIGN ligand inhibit high fat diet –induced adipose tissue and liver inflammation and steatosis in mice

High-fat diet (HFD)-induced inflammation is associated with a variety of health risks. The systemic pentraxin serum amyloid P (SAP) inhibits inflammation. SAP activates the high affinity IgG receptor Fc γ receptor I (FcγRI; CD64) and the lectin receptor DC-SIGN (CD209). Here, we show that for mice on a HFD, injections of SAP and a synthetic CD209 ligand (1866) reduced HFD-increased adipose and liver tissue inflammation, adipocyte differentiation, and lipid accumulation in adipose tissue. HFD wors ened glucose tolerance tests and caused increased adipocyte size; for mice on a HFD, SAP improved glucose tolerance tests and reduced adipocyte size.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research