The importance of pseudocapsule preservation during hysteroscopic myomectomy

Publication date: Available online 17 September 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Andrea Tinelli, Alessandro Favilli, Ricardo B Lasmar, Ivano Mazzon, Sandro Gerli, Xiang Xue, Antonio MalvasiAbstractMinimally invasive techniques for myomectomy are based on the rationale of preserving the myometrial integrity, in order to spare muscular and fibro-neurovascular myometrial fibers and ensure complete and bloodless myoma removal. Post-operative myometrial vascularization is crucial in injured muscle regeneration. The post-surgical myometrial healing is needful for uterine reproductive function. Neurotransmitters and neurofibers were analyzed in the myoma pseudocapsule surrounding fibroid. They activate signaling molecule synthesis and release which, in turn, promote cell activation and induce muscle regeneration and growth. Pseudocapsule damage during myomectomy may lead to a reduction of neuropeptides and neurofibers at the hysterotomic site, to a poor physiological myometrial healing, with more fibrosis due to hypoxia, ischemia and necrosis.These pathophysiological events cause deficit in myometrial neurotransmission, muscular impulse and contractility, with ultimately impaired uterine muscle function during pregnancy, labor and delivery. Hence, during myomectomy, all manipulations should be performed as precisely and bloodlessly as possible, avoiding extensive, high wattage diathermocoagulation or excessive tissue manip...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research

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ConclusionRRA must be initiated within 58 days after surgery in patients with high-risk DTCs. Under this approach, risk of SIR and associated mortality risk may be reduced. RRA timing for women in reproductive ages with low/intermediate risk groups may be planned according to their pregnancy/breastfeeding intent. For other low/intermediate risk groups, they can safely proceed according to the capacity of the medical facility and related logistical considerations.ResumenIntroducciónEs difícil adoptar un enfoque científico basado en la evidencia con respecto al intervalo de aplicación de la ablaci...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
ConclusionsSerum activins and follistatin were significantly altered with EP and activin-AB could be a promising marker for the diagnosis of EP.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
We present maternal and offspring data from 24 included studies, which have been quantitatively analysed after study quality assessment, to identify relationships between maternal diet and offspring body weight (BW), feeding behaviour and glycaemic control. In 11 data sets, exposure to NNS reduced maternal BW during pregnancy, with no effect on litter outcomes. Meta-analyses on offspring BW during weaning (1123 offspring) and adulthood (646 offspring) identified small decreases in BW for both sexes. Subgroup analyses revealed reductions in BW of rat, but not mouse models. High dosage appears to be a potential factor for re...
Source: Physiology and Behavior - Category: Physiology Source Type: research
In this study, we used liquid-chromatography tandem-mass spectrometry (LC-MS/MS) to screen for 16 steroid hormones in matched blood and blubber samples from free-ranging common bottlenose dolphins (Tursiops truncatus). Seven steroid hormones were detected and quantified, including two progestogens, two androgens, and three corticosteroids. Using principal components analysis (PCA), we explored relationships between hormones in both matrices and three physiological states: sexual maturity in males, pregnancy, and acute stress response. Plasma and blubber testosterone and its precursors, 17-hydroxyprogesterone and androstene...
Source: Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology - Category: Biochemistry Source Type: research
Publication date: Available online 20 October 2019Source: Reproductive ToxicologyAuthor(s): Vivi Flou Hjorth Jensen, Anne-Marie Mølck, Jens Lykkesfeldt, Johannes Josef Fels, Lene Andersen, Ruth Renaut, Fiona McGuigan, Kristina E. Åkesson, Ingrid Brück BøghAbstractThe aim was to investigate embryo-foetal effects of continuous maternal insulin-induced hypoglycaemia extending throughout gestation or until gestation day (GD)17 (typical last day of dosing during pre-clinical evaluation) providing comparator data for safety assessment of longer-acting insulin analogues in non-diabetic rats.Pregnant rats ...
Source: Reproductive Toxicology - Category: Toxicology Source Type: research
Conclusions: Surgical treatment of anomalous placement of the placenta in third-level hospitals can prevent adverse perinatal outcomes. Expectant management is possible in selected patients. PMID: 31631190 [PubMed - in process]
Source: Cirugia y Cirujanos - Category: Surgery Authors: Tags: Cir Cir Source Type: research
Publication date: October 2019Source: Pregnancy Hypertension, Volume 18Author(s): Michal Levy, Michal Kovo, Letizia Schreiber, Ilia Kleiner, Liron Koren, Giulia Barda, Eldar Volpert, Jacob Bar, Eran WeinerAbstractObjectiveIn attempt to deepen our understanding of the etiopathogenesis of preeclampsia we aimed to study the placental component and pregnancy outcomes in two consecutive pregnancies complicated by preeclampsia in the same patient.Study designPregnancy and placental reports of all pregnancies complicated by preeclampsia between 2008 and 2018 were reviewed. Included were only cases with recurrent preeclampsia in t...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Whether or not to circumcise your baby is a personal decision often determined by a variety of social, cultural, medical, or religious circumstances. Parents have the right to choose what they believe is best for their newborn and typically undergo extensive research before deciding what’s best for their family. So, what is the process of circumcision? Once parents decide to move forward, about an hour before the procedure, doctors use an anesthetic to numb the baby’s penis. The area is then sterilized and the excess skin on the penis is clamped and cut. Finally, the physician covers the penis in bandages or ga...
Source: Cord Blood News - Category: Perinatology & Neonatology Authors: Tags: babies pregnancy Source Type: blogs
[New Dawn] --Deputy Speaker admonishes traditional midwives
Source: AllAfrica News: Pregnancy and Childbirth - Category: OBGYN Source Type: news
HELEN CARROLL: The quads' first birthday is looming and, let's just say, some of the reaction Tracey from London encountered since announcing her pregnancy hasn't been terribly kind.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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