Chronic metformin reduces systemic and local inflammatory proteins and improves hypertension-related cardiac autonomic dysfunction

Metformin has been known to promote cardiovascular benefits in humans and animal models, even in non-diabetic subjects. However, its chronic effects on hypertension-related autonomic dysfunction remain poorly understood. Therefore, we evaluate the cardiac autonomic effects of chronic metformin in hypertensive rats.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 17, 2019 Category: Nutrition Authors: Phablo Wendell C. Oliveira, Glauciene J. de Sousa, Antonio Marcos Birocale, S ônia A. Gouvêa, Suely G. de Figueiredo, Gláucia R. de Abreu, Nazaré S. Bissoli Source Type: research