72 - Predicting Response to Resensitization of Radioiodine Resistant Thyroid Cancer With Whole Exome Sequencing

Publication date: October 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 7, SupplementAuthor(s): Kirstie Lithgow, Helen Huang, Denise Chan, Moosa Khalil, Mike Bristow, Vincent Dinculescu, Markus Eszlinger, Vicky Parkins, Ralf Paschke
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research

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Publication date: Available online 4 October 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Livia Lamartina, Giorgio Grani, Cosimo Durante, Sebastiano Filetti, David S CooperSummaryThe main purpose of cancer screening programmes should not be to detect all cancers, but to discover potentially fatal or clinically relevant cancers. The US Preventive Services Task Force recommends against screening for thyroid cancer in the general, asymptomatic adult population, as such screening would result in harms that outweigh any potential benefits. This recommendation does not apply to patients with symptoms or to indivi...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Does risk stratification in differentiated thyroid cancer require a more individualized approach?Journal of Clinical Endocrinology &Metabolism
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
ConclusionsThyroid alterations are frequently associated with anti PD-1 treatment in cancer patients. Regular thyroid assessment should be performed, particularly in the first months of treatment and in patients with a pre-existing thyroid disease.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
uesta A, Santos-Ocaña C, Hmadcha A, Soria B, Martín F, Gauthier BR, Martin-Montalvo A Abstract An inverse correlation between thyroid hormone levels and longevity has been reported in several species and reduced thyroid hormone levels have been proposed as a biomarker for healthy aging and metabolic fitness. However, hypothyroidism is a medical condition associated with compromised health and reduced life expectancy. Herein, we show, using wild-type and the Pax8 ablated model of hypothyroidism in mice, that hyperthyroidism and severe hypothyroidism are associated with an overall unhealthy status and ...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
Survivors of thyroid cancer experience anxiety related to diagnosis, treatment, and side effects, with ethnic minorities, women, younger patients, and the less educated worrying more, a new study indicates.Medscape Medical News
Source: Medscape Diabetes Headlines - Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news
ConclusionThis is the first report of the full triad of APS-2 developing in a genetically susceptible individual at the age of 78 after treatment with an anti-PD1 agent. Although scarcely reported, a literature review of similar reports seems to indicate a predilection for this syndrome in patients with HLA-DR4 serotypes. HLA Class II typing is not routinely recommended, but may provide useful predictive information for patients at risk of poly-endocrinopathy even in patients without a relevant personal or family history. Additional studies are required to determine if such testing would be useful and/or cost effective.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
Purpose of review Compared with adults, there is a two-fold to three-fold increased risk of malignancy for a pediatric patient undergoing evaluation of a thyroid nodule. In 2015, the American Thyroid Association published guidelines on the evaluation and management of pediatric patients with thyroid nodules and differentiated thyroid cancer. The goal of this clinical update is to review recent additions to the literature and propose opportunities how to best incorporate these findings into clinical practice. Recent findings Recent additions to the literature include assessment of ultrasound-based scoring systems to im...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: THYROID: Edited by Angela M. Leung Source Type: research
Purpose of review Our understanding of the molecular pathology events involved in thyroid cancer initiation and progression and its subtypes has markedly improved as a result of multiomic studies. Recently, long noncoding RNA (lncRNA) have been shown to have a role in cancer initiation and progression and have also been studied in thyroid cancer. Recent findings lncRNA are dysregulated in thyroid cancer. lncRNA have tumor suppressive and oncogenic function in thyroid cancer cells and play a role in some of the established genetic drivers of thyroid cancer initiation and progression. Lastly, some lncRNA are associated ...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: THYROID: Edited by Angela M. Leung Source Type: research
TSH suppression therapy is commonly used in the treatment of thyroid cancer, but is it associated with increased risks of circulatory events?Clinical Endocrinology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
ConclusionsThis meta-analysis did not suggest any increased risk of cancers associated with GLP-1RAs use in T2DM. The reduction in the risk of overall cancer associated with albiglutide needs to be examined further.
Source: Endocrine - Category: Endocrinology Source Type: research
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