Efficacy and safety of HDM SLIT-tablet in Japanese adults with allergic asthma

ConclusionThe trial demonstrated a favorable safety profile of the SQ HDM SLIT-tablet in Japanese adult patients with AA. The treatment appeared to be efficacious in patients requiring rescue medication (i.e., SABA) at baseline in the efficacy assessment using asthma exacerbation during ICS reduction (JapicCTI number 121847).
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research

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ConclusionsThe trial demonstrated a favorable safety profile of the SQ HDM SLIT tablet in Japanese adult patients with AA. The treatment appeared to be efficacious in patients requiring rescue medication (ie, short-acting β2-agonist) at baseline in the efficacy assessment using asthma exacerbation during inhaled corticosteroid reduction (JapicCTI number 121847).
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
ConclusionsSM are a  common sensitization in the study population and should be included in standard skin prick test arrays. Cross sensitization to house dust mites is limited and nasal symptoms are most frequent. Nasal provocation testing is necessary to secure clinical diagnosis of allergy and further research is ne eded to evaluate the clinical relevance of the high sensitization rates found for intradermal testing.
Source: Allergo Journal International - Category: Allergy & Immunology Source Type: research
Source: Journal of Asthma and Allergy - Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Idiopathic anaphylaxis (IA) is a rare condition that can be lethal.1Prophylactic regimens for frequent attacks are not yet standardized. These may include long-term systemic corticosteroids, high dose antihistamines, and mast cell stabilizers. Despite these regimens, patients may become corticosteroid dependent (20%) and develop potential side effects 2. Omalizumab is a monoclonal anti-IgE antibody which is indicated in uncontrolled moderate to severe persistent asthma3 and chronic idiopathic urticaria4.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
" Idiopathic anaphylaxis successfully treated with omalizumab". Ann Allergy Asthma Immunol. 2019 Sep 27;: Authors: Sanchez-Valenzuela MC, Garcia-Saucedo JC, Motoa G, Carrilo-Martin I, Gonzalez-Estrada A PMID: 31568858 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
In this study, we investigated the clinical manifestations and risk factors for anaphylaxis in PFAS in Korean patients with pollinosis. MATERIALS AND METHODS: Data were obtained from a nationwide cross-sectional study that previously reported on PFAS in Korean patients with pollinosis. Data from 273 patients with PFAS were collected, including demographics, list of culprit fruits and vegetables, and clinical manifestations of food allergy. We analyzed 27 anaphylaxis patients and compared them with patients with PFAS with oropharyngeal symptoms only (n=130). RESULTS: The most common cause of anaphylaxis in PFAS wa...
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
Although atopic dermatitis (AD) has been associated with increased risk of food allergy (FA), this association is not fully understood, and the predictors of severe reactions to foods are not clear. In a review of 18 population-controlled studies, the rate of food sensitization was up to 6 times higher in patients with AD vs healthy controls.1 A recent study identified a potential physiologic mechanism by demonstrating increased skin barrier dysfunction, measured by increased transepidermal water loss and reduced skin filaggrin levels, in patients with AD and FA.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
PMID: 31520770 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
Although atopic dermatitis (AD) has been associated with increased risk of food allergy (FA), this association is not fully understood and the predictors of severe FA are not clear. In a review of 18 population-controlled studies, the rate of food sensitization was up to 6 times higher in patients with AD versus normal controls.1 A recent study identified a potential physiologic mechanism by demonstrating increased skin barrier dysfunction, measured by increased transepidermal water loss and reduced skin filaggrin levels, in patients with AD and FA.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Anaphylaxis is considered idiopathic when there is no known trigger. The signs and symptoms of idiopathic anaphylaxis (IA) are identical to those of anaphylaxis due to a known cause and can include cutaneous, circulatory, respiratory, gastrointestinal, and neurologic symptoms. IA can be a frustrating disease for patients and healthcare providers. Episodes are unpredictable and differential diagnosis is challenging. Current anaphylaxis guidelines have little specific guidance regarding differential diagnosis and long-term management of IA.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
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