Ex-utero extracorporeal support as a model for fetal hypoxia and brain dysmaturity

ConclusionsSustained hypoxemia in fetal sheep leads to altered cerebrovascular resistances and loss of brain mass, similar to human fetuses with CHD. This unique model provides opportunities to investigate the pathology underlying CHD associated brain dysmaturity, as well as to evaluate potential fetal neuroprotective therapies.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research

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We present a retrospective review of 13 consecutive children who underwent implantation of VAD between 2001 and 2018 in our center. The median age was 12  years (1–17 years), weight was 45 kg (10–82 kg). Etiologies of heart failure were dilated cardiomyopathy (CMP) (n = 8), myocarditis (n = 2), ischemic CMP (n = 1), restrictive CMP (n = 1) and congenital heart disease (n = 1). Pre-implantation ECMO was used in 5, mechanical ventilation in 4, renal replacement therapy in 2 and IABP in 1. Devices used were: Berlin Heart EXCO...
Source: Journal of Artificial Organs - Category: Transplant Surgery Source Type: research
(CNN) — Americans spent $1.4 billion on the most popular brands of children’s fruit drinks and flavored waters last year. Yet according to nutritional guidelines, none of the drinks were healthy. Why would loving parents do this? Perhaps because US beverage companies spent $20.7 million to advertise fun, fruity drinks with added sugars to families in 2018, according to Children’s Drink Facts 2019, a new report from the University of Connecticut’s Rudd Center for Food Policy and Obesity. “I know that parents want their children to be healthy, but the sweetened drink market is just incredibly co...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Syndicated CBSN Boston CNN juice Source Type: news
Credit: Busani Bafana/IPSBy Esther Ngumbi and Ifeanyi NsoforILLINOIS, United States / ABUJA, Oct 16 2019 (IPS) United Nations World Food Day is celebrated around the world on October 16 under the theme: “Our Actions ARE Our Future. Healthy Diets for a Zero Hunger World”. This theme is timely, especially, because across Africa and around the world, there has been a gradual rise in malnutrition and diet-related non communicable diseases, as highlighted in The Lancet study and a United Nations Report published earlier this year. While 45 percent of deaths in children are from nu...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Food & Agriculture Global Headlines Health World Food Day Source Type: news
What does the future hold for academic medical centres (AMCs) in the US? Can they survive? Dr. Stephen Klasko, President and CEO of Jefferson Health, called the closure of the Hahnemann School of Medicine a “national warning sign” [1]. Other academic institutions, such as Emory University and Vanderbilt University, have begun to distance themselves from their associated hospital systems due to financial constraints. Our institution, the University of Louisville School of Medicine, has been involved in a several year process to save programs in heart disease and solid organ transplantation at a financially const...
Source: Injury - Category: Orthopaedics Authors: Tags: Editorial Source Type: research
We reported two patients with advanced heart disease who developed CIED infection dueStaphylococcus epidermidis while awaiting for orthotopic heart transplantation (OHT). Both patients were managed with a different approach. They were treated with antibiotic therapy and had their CIED removal postponed until OHT. Both patients were kept on suppressive antibiotic treatment until undergoing simultaneous OHT and removal of infected CIED. None of the patients had infection recurrence. Large studies are needed to assess whether the approach of delaying CIED removal until OHT is safe among carefully selected patients with CIED infection.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research
Publication date: Available online 10 October 2019Source: Canadian Journal of CardiologyAuthor(s): Marie-A. Chaix, Michael A. Gatzoulis, Gerhard-Paul Diller, Paul Khairy, Erwin N. OechslinAbstractEisenmenger syndrome is the most severe and extreme phenotype of pulmonary arterial hypertension associated with congenital heart disease. A large non-restrictive systemic left-to-right shunt triggers the development of pulmonary vascular disease, progressive pulmonary arterial hypertension and increasing pulmonary vascular resistance at the systemic level, which ultimately results in shunt reversal. Herein, we review the changing...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
A new blood filtration technology may prove to be life-saving for patients whose normally healthy inflammatory response to injury or illness has gone into overdrive, resulting in fatally high levels of cytokines in their blood. In an interview with MD+DI, Dr. Phillip Chan, MD, PhD, CEO of CytoSorbents Corp., explained that inflammation, and the production of substances called cytokines that drive inflammation, are the body’s natural response to heal injury or infection. But sometimes, the inflammatory response is so severe in such conditions as sepsis and infection, burn injuries, trauma, pancreatitis, li...
Source: MDDI - Category: Medical Devices Authors: Tags: Cardiovascular Source Type: news
Abstract Pulmonary hypertension is a term used to describe a complex multifactorial group of conditions diagnosed by an elevated mean pulmonary artery pressure of 20 mm Hg or higher on right heart catheterization. The diagnosis of pulmonary hypertension in pregnancy is important, as it is associated with high rates of maternal morbidity and mortality, even with modern management. Diagnostic testing is important for establishing the diagnosis, type, and severity of pulmonary hypertension, which in turn, dictates treatment options. Echocardiographic assessment is the first step in diagnosis and the gold standard for...
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
In the modern era, renal and liver transplant candidates present with a greater medical complexity driven in part by a higher prevalence of cardiovascular conditions, including coronary artery disease, valvular heart disease, and cardiomyopathies. In fact, cardiovascular disease is the most common cause of death after kidney transplantation worldwide. Similarly, an increase in the number of patients being listed with end-stage liver disease from nonalcoholic steatohepatitis and a rising model for end-stage liver disease scores at the time of liver transplant in the United States parallel an increasing cardiovascular diseas...
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research
Fitbit or Apple Watch for running? Garmin or Misfit for swimming? Sleep Cycle or Sleep as Android for sleep tracking? What about measuring heart rate, blood pressure, or tracking how to cut out stress from your life? Dozens of gadgets on the healthcare wearable market promise you a healthier lifestyle, but it’s easy to go astray in the jungle of digital health gadgets. Let me show you my top choices when it comes to health wearables and trackers. Guidance in the health wearable universe By now, I have tested and used more than a hundred devices and gadgets that measure health parameters or vital signs. Thus,...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Health Sensors & Trackers Portable Diagnostics activity fitness fitness trackers Health 2.0 Healthcare Innovation meditation mental health Personalized medicine sleep sleep optimization sleep tracking stress technology wear Source Type: blogs
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