Differential Cytokine and Metabolite Production by Cervicovaginal Epithelial Cells Infected with Lactobacillus crispatus and Ureaplasma urealyticum.

CONCLUSION: Infection of cervicovaginal epithelial cells by U. urealyticum stimulates production of ammonia from urea and induces elevated IL-8 production possibly leading to significantly higher cytotoxicity. In contrast, L. crispatus appeared protective against HeLa cell inflammation and death, producing more D-lactate and less IL-8, consistent with a role for L. crispatus in promoting vaginal floral health and reducing infection/inflammation-associated preterm birth. PMID: 31525453 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31525453?dopt=Abstract

Source: Anaerobe - September 12, 2019 Category: Microbiology Authors: Cavanagh M, Amabebe E, Anumba DOC Tags: Anaerobe Source Type: research

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