Usefulness of the frontal lobe bottom and cerebellum tuber vermis line as an alternative clue to set the axial angle parallel to the AC –PC line in I-123 IMP SPECT imaging: a retrospective study

AbstractWe aimed to investigate whether the frontal lobe bottom and cerebellum tuber vermis (FLB –CTV) line on brain perfusion scintigraphy, using iodine-123 isopropyl iodoamphetamine single photon emission computed tomography (I-123 IMP SPECT) images, is useful to determine an axial angle parallel to the anterior commissure-posterior commissure (AC–PC) line. We measured the angular differe nces between the AC–PC line and the FLB–CTV line on midsagittal brain magnetic resonance imaging (MRI) scans of 100 patients. We also evaluated the angular differences of the FLB–CTV line between the IMP SPECT images and the computed tomography for attenuation correction (CTAC) images in the s ame 100 patients, using a reference line on the CTAC images. Furthermore, the inter-reader reproducibility of the FLB–CTV line measurements on IMP SPECT images of 50 patients between two readers was evaluated using the intra-class correlation coefficient (ICC) and 95% confidence interval (CI). The mean and standard deviation of the angular differences between the AC–PC and FLB–CTV lines on midsagittal brain MRI scans were − 1.24° and 1.14°, respectively. The mean and the standard deviation of the angular differences of the FLB–CTV line in the IMP SPECT and CTAC images were 0.87° a nd 0.48°, respectively. The ICC of the FLB–CTV line measurements on IMP SPECT images was 0.99 (95% CI 0.98–0.99). We demonstrated that ...
Source: Radiological Physics and Technology - Category: Physics Source Type: research

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AbstractFunctional neuroimaging techniques (i.e. single photon emission computed tomography, positron emission tomography, and functional magnetic resonance imaging) have been used to assess the neural correlates of anosognosia in mild cognitive impairment (MCI) and Alzheimer ’s disease (AD). A systematic review of this literature was performed, following the Preferred Reporting Items for Systematic Reviews and Meta Analyses statement, on PubMed, EMBASE, and PsycINFO databases. Twenty-five articles met all inclusion criteria. Specifically, four brain connectivity and 2 1 brain perfusion, metabolism, and activation ar...
Source: Neuropsychology Review - Category: Neuroscience Source Type: research
Conclusions Several model systems are now available to characterize the MSC-tumour interplay in the TME. These offer early promise in establishing robust preclinical platforms for the identification of crucial molecular pathways and for the assessment of clinical efficacy of novel drugs to inhibit cancer development and progression. However, selection of the right model for a given study should be shaped on the purpose, and should also consider fixed biological, biochemical, and biophysical parameters according to the specific tumour type. Finally, in order to get reliable and useful results to be translated to the clinic...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Maria Mayoral1†, Aida Niñerola-Baizán2,3†, Berta Marti-Fuster2,3, Antonio Donaire4,5, Andrés Perissinotti1, Jordi Rumià6, Núria Bargalló5,7, Roser Sala-Llonch3, Javier Pavia1,2,5, Domènec Ros2,3,5, Mar Carreño4,5, Francesca Pons1,5 and Xavier Setoain1,2,5* 1Nuclear Medicine Department, Hospital Clínic, Barcelona, Spain 2Biomedical Imaging Group, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Barcelona, Spain 3Biophysics and Bioengineering Unit, Biomedicine Department, School of Medicine...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion and Future Perspectives Although interesting data have come from pharmacogenetics, neuroimaging and the interaction of both fields of study, few converging findings are available that describe the antipsychotic treatment response and resistance mechanisms in schizophrenia (DeLisi and Fleischhacker, 2016). Based on the available evidence, the results from both neuroimaging and pharmacogenetic/pharmacogenomic studies point to an overlap in the neurobiological vulnerability risk factors influencing the antipsychotic drug response in schizophrenia and the risk factors underlying schizophrenia itself. Currently for ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Moyamoya disease (MMD) and Moyamoya syndrome (MMS) are referring to a progressive steno-occlusive vasculopathy at terminal portions of the bilateral internal carotid arteries and their proximal branches with prominent collateral artery formation. They can be found throughout the world and cause irreversible damage to the cerebral hemodynamics due to the progressive nature. Prompt diagnosis and accurate assessment could significantly improve the prognosis of MMD and MMS. Some imaging modalities could be used for diagnosis and nonquantitative evaluation of MMD and MMS, such as conventional computed tomography (CT) and magnet...
Source: Journal of Computer Assisted Tomography - Category: Radiology Tags: Neuroradiology Source Type: research
Publication date: 2018 Source:Handbook of Clinical Neurology, Volume 152 Author(s): Linda Chang, Dinesh K. Shukla Human immunodeficiency virus (HIV) enters the brain early after infecting humans and may remain in the central nervous system despite successful antiretroviral treatment. Many neuroimaging techniques were used to study HIV+ patients with or without opportunistic infections. These techniques assessed abnormalities in brain structures (using computed tomography, structural magnetic resonance imaging (MRI), diffusion MRI) and function (using functional MRI at rest or during a task, and perfusion MRI with or witho...
Source: Handbook of Clinical Neurology - Category: Neurology Source Type: research
Publication date: Available online 14 February 2018 Source:The Veterinary Journal Author(s): R. Dockx, C. Baeken, R. Duprat, F. De Vos, J.H. Saunders, I. Polis, K. Audenaert, K. Peremans Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a treatment for several neuropsychiatric disorders in human beings, but the neurobiological effects of rTMS in dogs have not been investigated to date. A proof of concept study was designed to evaluate the effect of rTMS on cerebral perfusion, measured with single photon emission computed tomography (SPECT), in dogs. An accelerated high frequency (aHF)-rTMS (20Hz) pr...
Source: The Veterinary Journal - Category: Veterinary Research Source Type: research
Abstract Rationale: Holmes’ tremor is an uncommon neurologic disorder following brain insults, and its pathogenesis is undefined. The interruption of the dento-rubro-thalamic tract and secondary deterioration of the nigrostriatal pathway are both required to initiate Holmes’ tremor. We used nuclear medicine imaging tools to analyze a patient with concurrent infarction in different zones of each side of the thalamus. Finding whether the paramedian nuclear groups of the thalamus were injured was a decisive element for developing Holmes’ tremor. Patient concerns: A 36-year-old woman was admitted to our ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
AbstractNeurological dysfunction following epileptic seizures is a well-recognized phenomenon. Several potential mechanisms have been suggested to explain postictal dysfunction, with alteration in cerebral blood flow being one possibility. These vascular disturbances may be long lasting and localized to brain areas involved in seizure generation and propagation, as supported by both animal and human studies. Therefore, measuring perfusion changes in the postictal period may help localize the seizure onset zone. Arterial spin labelling is a non-invasive, rapid and reproducible magnetic resonance imaging technique that measu...
Source: Brain - Category: Neurology Source Type: research
A healthy, functional microcirculation in combination with nonobstructed epicardial coronary arteries is the prerequisite of normal myocardial perfusion. Quantitative assessment in myocardial perfusion and determination of absolute myocardial blood flow can be achieved noninvasively using dynamic imaging with multiple imaging modalities. Extensive evidence supports the clinical value of noninvasively assessing indices of coronary flow for diagnosing coronary microvascular dysfunction; in certain diseases, the degree of coronary microvascular impairment carries important prognostic relevance. Although, currently positron em...
Source: Circulation: Cardiovascular Imaging - Category: Radiology Authors: Tags: Computerized Tomography (CT), Echocardiography, Magnetic Resonance Imaging (MRI), Nuclear Cardiology and PET Advances in Cardiovascular Imaging Source Type: research
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