Pharmacological prospection in-vitro of Lamiaceae species against human pathogenic fungi associated to invasive infections

Publication date: Available online 17 September 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Sthéfane Guimarães Araújo, William Gustavo Lima, Maria Eduarda Amaral Pinto, Marcela Ísis Morais, Nívea Pereira de Sá, Susana Johann, Carlos Augusto Rosa, Luciana Alves Rodrigues dos Santos LimaAbstractThe medical importance of invasive fungal diseases (IFD) contrasts with the limited therapeutic arsenal available and the increasing resistance rate of pathogenic fungi. Thus, the search for news antifungal drugs is imperative. Many studies highlight the antimicrobial activity of plants from Lamiaceae family such as Melissa officinalis, Mentha sp., Ocimum basilicum, Plectranthus barbatus and Rosmarinus officinalis, but the antifungal potential these species remains still poorly known. The present study was to evaluate the effect of these Lamiaceae species against fungi involved in IFDs. Fresh plants were macerated with ethanol and the extract obtained was partitioned with different solvents. Phytochemical analyzes were conducted and the volatile compounds were investigated by gas chromatography/mass spectrometry (GC/MS). Subsequently, the standardized vegetal material was used to evaluate the antifungal activity through minimum inhibitory concentration (MIC) determination. Ethanol extract of M. officinalis, Mentha sp., O. basilicum, and R. officinalis showed good to moderate activity against Paracoccidioides spp. (MIC 62.5-500 μg/mL). The spectrum of antifung...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research