A registry-based cohort study of pulmonary tuberculosis treatment outcomes in Istanbul, Turkey.

A registry-based cohort study of pulmonary tuberculosis treatment outcomes in Istanbul, Turkey. Jpn J Infect Dis. 2013;66(2):115-20 Authors: Babalik A, Kilicaslan Z, Caner SS, Gungor G, Ortakoylu MG, Gencer S, McCurdy SA Abstract The aim of this study is to evaluate the treatment outcomes and identify factors associated with adverse tuberculosis treatment outcomes for bacteriologically confirmed pulmonary tuberculosis. Treatment outcomes of pulmonary tuberculosis were evaluated retrospectively among 11,186 smear- and/or culture-positive patients treated between 2006 and 2009 in Istanbul, Turkey. Adverse treatment outcomes were identified in 1,010 (9.0%) patients including death (1.8%), treatment default (6.1%), and treatment failure (1.1%). Factors associated with adverse treatment outcomes included being born abroad (odds ratios [OR], 5.38; 95% confidence intervals [CI], 3.67-7.91), history of tuberculosis treatment (OR, 3.77; 95% CI, 3.26-4.36), age> 65 years (OR, 2.79; 95% CI, 2.21-3.53), and male gender (OR, 1.91; 95% CI, 1.59-2.27). Death was most strongly associated with age> 65 years (OR, 45.1; 95% CI, 27.0-75.6), followed by treatment default with history of interrupted treatment (OR, 11.6; 95% CI, 8.94-15.1), and treatment failure with prior history of treatment failure (OR, 17.1; 95% CI, 6.97-41.6). Multidrug resistance was strongly associated with adverse treatment outcomes (OR, 10.8; 95% CI, 8.02-14.6). Age> 65 years, male sex, being born...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research

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Background: Diabetes mellitus (DM) has an influence on many aspects of tuberculosis (TB).Objectives: to correlate the influence of diabetes mellitus on sputum conversion rate and antituberculous drug resistance.Methods: The study comprised 194 pulmonary tuberculosis (PTB) patients divided in two groups, i.e. the group of TB associated with DM and the group of patients affected only by TB. Sputum smear and liquid culture (MGIT 960) examination were performed at TB diagnosis and subsequently at completion of the initial phase as well as during the continuation phase of TB treatment. Drug sensitivity test (DST) was also perfo...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
Conclusions: About half of the MDR-TB cases in our centre achieved successful treatment outcome. Poor treatment outcome was seen in male and smoker.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
Tuberculosis (TB) is a leading cause of death and morbidity worldwide. Of the 10 million incidence cases of TB estimated in 2017, 10% were in children.The diagnosis of TB in the paediatric population remains challenging due to the paucibacillary nature of the disease. Culture confirmation is low for both pulmonary and extrapulmonary disease; 30.3% and 19.4% respectively resulting in empiric treatment for presumed TB. Mediastinal TB is a common presentation of TB in children but difficult to access for sampling.A retrospective case review of all children (
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
Conclusions: In Hanoi city, drug resistance-conferring mutations are prevailing differently depending on MTB lineages and treatment history. Confirmation of sterilizing cure is important for better TB control.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
This study is to evaluate the performance of GeneXpert MTB/RIF (GXP) assay versus Real-time PCR MTBC/NTM (Lytestar) and other conventional methods in the diagnosis of Mycobacterium tuberculosis (TB). We conducted a retrospective cross-sectional analysis of patients who were investigated for TB via bronchoalveolar lavage between March to December 2018 in a single tertiary pulmonary centre in Malaysia. Results of GXP were analyzed base on patient’s demographic characteristics and other diagnostic methods. 33 of total 72 patients were diagnosed with pulmonary tuberculosis either through rapid DNA testing via GXP or real...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
We report the case of a 10-year-old child treated for latent tuberculosis infection (LTBI) with pyrazinamide (PZA) and levofloxacin after contact with a smear-positive multidrug-resistant tuberculosis adult. Over the course of the treatment, the patient developed a drug-induced fulminant hepatitis attributed to the combination of PZA and levofloxacin. This case highlights the hepatotoxicity of the association of second-line anti-TB treatment in children.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Antimicrobial Reports Source Type: research
Conclusions: MDR-TB can be cured successfully with modified DOTS-Plus strategy and requires much effort from both the patients and health-care workers. It can be an alternative model for treating MDR-TB patients in private sector.
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
ConclusionThe frequency of mutations in MTB in the coastal region of Andhra Pradesh, India, is similar to that in retreatment cases from most settings, with close to 80% in rpoB codon 516, 526, and 531, and over 80% in codons katG 315 and/or inhA promoter. The increase in INH monoresistance underlines the need for greater enforcement of national TB control programs.
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research
CONCLUSION: The frequency of mutations in MTB in the coastal region of Andhra Pradesh, India, is similar to that in retreatment cases from most settings, with close to 80% in rpoB codon 516, 526, and 531, and over 80% in codons katG 315 and/or inhA promoter. The increase in INH monoresistance underlines the need for greater enforcement of national TB control programs. PMID: 31421108 [PubMed - as supplied by publisher]
Source: Braz J Infect Dis - Category: Infectious Diseases Authors: Tags: Braz J Infect Dis Source Type: research
Abstract Background &objectives: Rapid detection of drug resistance in Mycobacterium tuberculosis (MTB) is essential for the efficient control of tuberculosis. Hence, in this study a nested-allele-specific (NAS) PCR, nested multiple allele-specific PCR (NMAS-PCR) and multiple allele-specific (MAS) PCR assays were evaluated that enabled detection of the most common mutations responsible for isoniazid (INH) and rifampicin (RIF) resistance in MTB isolates directly from clinical specimens. Methods: Six pairs of primers, mutated and wild type, were used for the six targets such as codon 516, 526 and 531 of rpo...
Source: Indian J Med Res - Category: Research Authors: Tags: Indian J Med Res Source Type: research
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