Multi-drug approaches to NASH: what's in the development pipeline?

Multi-drug approaches to NASH: what's in the development pipeline? Expert Opin Investig Drugs. 2019 Sep 16;: Authors: Johnston MP, Patel J, Byrne CD Abstract Introduction The pandemic of obesity over the last two decades has triggered a rise in prevalence of non-alcoholic fatty liver disease (NAFLD). NAFLD is associated with liver-related- and cardiovascular complications. Despite this, the first licensed drug for NAFLD is yet to be approved. Given the scale of the problem and unmet needs, there is a myriad of agents in the development pipeline. Areas covered We discuss promising agents in early phase clinical trials and categorize these agents based on their action on steatosis, steatohepatitis and fibrosis. Furthermore, given the multisystemic nature of NAFLD, we consider the effects of these agents on the liver, their cardiometabolic effects, and the potential future strategies of combination therapies. Expert opinion The paradigm for the ideal drug is the targeting of both steatohepatitis and fibrosis and the amelioration of cardiometabolic risk factors. New drugs that confer benefit in NASH, must also be tested for their effects on T2DM and CVD. The treatment of NASH will become analogous to the treatment of hypertension; it is very likely that multiple classes of drugs targeting different mechanistic pathways will be necessary because no single agent is likely to control all aspects of this complex liver disease. PMID: 31524533 [PubMed - as supp...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research

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Source: Stem Cell Research - Category: Stem Cells Source Type: research
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Source: Journal of Membrane Science - Category: Materials Science Source Type: research
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Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
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Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
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Source: LWT Food Science and Technology - Category: Food Science Source Type: research
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Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
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