Is the ‘oestro-androgenic’ hormone dehydro-epiandrosterone sulphate (DHEAS) the intracrine regulator of implantation and early pregnancy?: a prospective study in women undergoing IVF

Decidualization of endometrial-stroma is necessary for successful implantation. Very high levels of dehydro-epiandrosterone (DHEA), which inhibit endometrial-stromal cell differentiation via prevention of glucose-flux through pentose-phosphate-pathway, could be a probable cause for higher incidence of implantation failure among PCOS women. Contrarily, low DHEA women with diminished ovarian-reserve, when supplemented with DHEA show significant reduction in early miscarriage rates. Sulphonated-DHEA (DHEAS) is more stable than DHEA and is the most abundant circulating 'oestro-androgenic' steroid precursor for estrogen production in humans.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research