Stem Cell Therapy for Chronic Skin Wounds in the Era of Personalized Medicine: from Bench to Bedside

Publication date: Available online 17 September 2019Source: Genes &DiseasesAuthor(s): Elam Coalson, Elliot Bishop, Wei Liu, Yixiao Feng, Mia Spezia, Bo Liu, Yi Shen, Di Wu, Scott Du, Alex Li, Zhenyu Ye, Ling Zhao, Daigui Cao, Alissa Li, Ofir Hagag, Alison Deng, Winny Liu, Mingyang Li, Rex C. Haydon, Lewis ShiAbstractWith the significant financial burden of chronic cutaneous wounds on the healthcare system, not to the personal burden mention on those individuals afflicted, it has become increasingly essential to improve our clinical treatments. This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient. The most promising potential treatment options rely on stem cell-based therapies. Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function. Clinical approaches involving stem cells could thus be utilized in some cases to improve a body’s inhibited healing capacity. We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential. Given the current problems and complications presented by chronic wounds, we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care.
Source: Genes and Diseases - Category: Genetics & Stem Cells Source Type: research

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Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine 3d printing artificial food brain-computer interface cyborg digital tattoos drug development exoskeleton gamification google glass health insurance Healthcare Innovation List Medical education medical techn Source Type: blogs
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Source: Current Reviews in Musculoskeletal Medicine - Category: Orthopaedics Source Type: research
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Source: Stem Cells - Category: Stem Cells Authors: Tags: Translational and Clinical Research Source Type: research
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Source: Stem Cells - Category: Stem Cells Authors: Tags: TISSUE ‐SPECIFIC STEM CELLS Source Type: research
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Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - Category: Surgery Authors: Source Type: research
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Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
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Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
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Source: Biochemical Engineering Journal - Category: Biochemistry Source Type: research
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Source: Current Eye Research - Category: Opthalmology Authors: Tags: Curr Eye Res Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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