Imaging of Endometriosis

Endometriosis is a common cause of chronic pelvic pain, dysmenorrhea and infertility. Although 6 –10% of women of child bearing age are affected by the disease, and even more in the group of patients with fertility problems, diagnosis is often delayed and treatment can be challenging. Depending on the complaints, extent of disease and the goals of treatment (fertility treatment, pain reducti on, …), both medical and surgical options are available for the management of this pathology and often a  multidisciplinary approach will be necessary. Although diagnostic laparoscopy with histologic confirmation remains the golden standard for diagnosis, several imaging techniques can aid in the preoperative surgery planning. This presentation will focus mainly on the use of magnetic resonance imaging in the work-up of endometriosis. Published on 2019-09-18 10:35:43
Source: Journal of the Belgian Society of Radiology - Category: Radiology Source Type: research

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Conclusion Dyspareunia and acyclic pain were independent factors of correlation with high scores in the EHP-30 questionnaire, reflecting a worse quality of life.Resumo Objetivo Avaliar a exist ência de associação entre os achados ultrassonográficos e os fatores epidemiológicos e clínicos com os resultados obtidos no questionário EHP-30 em mulheres com diagnóstico de endometriose ovariana. Métodos Realizou-se um estudo observacional transversal entre julho de 2012 emaio de 2015, no qual as pacientes com dor pélvica crônica com imagem sugestiva de end...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
ConclusionTraditionally only pathologies of the uterus and ovaries are assessed during a routine pelvic ultrasound. Here we demonstrate that the routine ultrasound examination can easily be extended beyond the uterus and ovaries into the posterior and anterior pelvic compartments to evaluate structural mobility and to look for deep infiltrating endometriotic nodules, so women suffering from deep infiltrating endometriosis can benefit from a pre-operative diagnosis and subsequently a single, well-planned procedure in the hands of a well-prepared team.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Endometriosis is an estrogen-dependent disease with symptoms of dysmenorrhea, chronic pain, and infertility that affects 6% to 10% of women of reproductive age. Medical or surgical therapy, such as administration of an anti-gonadotropin or ovarian cystectomy, provide effective pain relief. However, neither therapy can be used for patients wishing to become pregnant. Despite the high morbidity, the pathogenesis of endometriosis has not been well elucidated. Several inflammatory cytokines are reported to participate in the onset of endometriosis. Here, we examined the role of interleukin (IL)-1/IL-33 signaling in the develop...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The modulation of endometriosis by lncRNA MALAT1 via NF-κB/iNOS. Eur Rev Med Pharmacol Sci. 2019 May;23(10):4073-4080 Authors: Yu J, Chen LH, Zhang B, Zheng QM Abstract OBJECTIVE: Endometriosis (Ems) is one benign disorder that frequently leads to chronic pelvic pain, dysmenorrhea or even infertility. Featured as the ectopic growth of active endometrial tissues on tissues beyond the muscular layer, Ems has complicated pathogenesis mechanisms that are not fully illustrated. Long non-coding (lnc) RNA MALAT1 participates in various biological activities, including cell growth, proliferation, apoptos...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Publication date: Available online 27 May 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Aurélie Comptour, Bruno Pereira, Céline Lambert, Pauline Chauvet, Anne-Sophie Gremeau, Jean-Luc Pouly, Michel Canis, Nicolas BourdelABSTRACTStudy objectiveTo investigate predictive factors for change in quality of life (QoL) between pre and post-operative periods in patients with endometriosisDesignProspective and multicenter cohort studySetting5 districts including a tertiary referral center, private and general public hospitalsPatient981 patients, aged 15-50 years, underwent laparoscopic treatment (prefe...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
(Abstracted from J Minim Invasive Gynecol 2019;26:71–77) The primary sequelae of endometriosis are infertility and chronic pelvic pain (CPP). Nearly 40% of women with endometriosis are infertile, and 71% to 87% have CPP.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: GYNECOLOGY: OPERATIVE GYNECOLOGY Source Type: research
Authors: Bulun SE, Yilmaz BD, Sison C, Miyazaki K, Bernardi L, Liu S, Kohlmeier A, Yin P, Milad M, Wei J Abstract Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into the lower abdominal cavity. Endometriosis is the most common cause of chronic pelvic pain in women and is associated with infertility. The underlying pathologic mechanisms in the intracavitary endometrium and extra-uterine endometriotic tissue involve defectively progr...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
ConclusionsWe have identified menstrual cycle- and endometriosis-associated protein changes linked to various cellular processes that are potential biomarkers and that provide insight into the biology of endometriosis. Our data indicate that the markers tested, whilst not useful alone, have improved diagnostic accuracy when used in combination and demonstrate menstrual cycle specificity. Tissue heterogeneity and blood contamination is likely to have hindered biomarker discovery, whilst a small sample size precludes accurate determination of performance by cycle phase. Independent validation of these biomarker panels in a l...
Source: Clinical Proteomics - Category: Biochemistry Source Type: research
Conclusions and Relevance Cystectomy of ovarian endometriomas has been the first-line treatment for management for many years because it provides improved pain relief, reduces recurrence rates, and was thought to be favorable in in vitro fertilization. However, a growing body of evidence is demonstrating benefit, or at least no harm, in expectant management for asymptomatic patients with small, stable endometriomas. Medical management is often very effective and appropriate first line. When surgical intervention is appropriate, careful ovarian cyst excision with goal of ovarian tissue preservation and treatment of additi...
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: CME ARTICLES Source Type: research
Abstract Endometriosis is characterized by extra-uterine growth of endometrial tissue accompanied by adverse clinical manifestations including chronic pelvic pain and infertility. Retrograde menstruation, the efflux of endometrium into the peritoneal cavity during menstruation, is believed to contribute to implantation of endometrial tissue and formation of endometriotic lesions at ectopic sites. While it is established through various rodent and non-human primate models that endometrial tissue fragments, as well as non-dissociated stroma and glands, are capable of seeding endometriosis in a manner mimicking retro...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
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