Cetuximab and Radiation Therapy in Head and Neck Cancer

We read with great interest the Oncology Scan article by Anderson et  al.1 The paper focused on the latest findings indicating that radiation therapy plus cetuximab led to inferior overall survival in human papillomavirus (HPV)–positive patients with oropharyngeal cancer (OPC), compared with standard concurrent platinum-based chemotherapy. The authors summarize an d comment on the recent results of 2 large prospective randomized trials2,3 published in January 2019 in The Lancet. Both trials were based on the hypothesis that substituting cisplatin with cetuximab could offer a valid, but less toxic, alternative as a deintensification strategy in patients with H PV-positive favorable disease.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Comment Source Type: research

Related Links:

n Human papillomavirus (HPV) infection is the cause of a growing percentage of head and neck cancers (HNC); primarily, a subset of oral squamous cell carcinoma, oropharyngeal squamous cell carcinoma, and laryngeal squamous cell carcinoma. The majority of HPV-associated head and neck cancers (HPV + HNC) are caused by HPV16; additionally, co-factors such as smoking and immunosuppression contribute to the progression of HPV + HNC by interfering with tumor suppressor miRNA and impairing mediators of the immune system. This review summarizes current studies on HPV + HNC, ranging from potential modes of oral transmission of ...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Conclusion: PDX from OPSCC preserves important molecular characteristics of the human primary tumor. Radiosensitivity were in accordance with clinically observed treatment response. The PDX model is a clinically relevant surrogate model of head and neck cancer. Perspectives include increased understanding of disease biology, which could lead to development of novel treatments and biomarkers. PMID: 31510843 [PubMed - as supplied by publisher]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
Oropharynx squamous cell carcinoma (OPSCC) has become the predominant subsite for head and neck mucosal cancers (HNC) due to the rise of human papillomavirus (HPV) related disease. Previous studies have sugges...
Source: Journal of Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Authors: Tags: Original research article Source Type: research
This article focuses on the epidemiology, transmission, risk factors, and clinical presentation of HPV-associated oropharyngeal SCC, and provides an update on HPV vaccination in the context of the new head and neck cancer epidemic.
Source: Journal of the American Academy of Physician Assistants - Category: Primary Care Tags: CME: Oncology Source Type: research
In this issue of JAMA Otolaryngology –Head&Neck Surgery, Masroor at al explore the outcomes associated with adherence to the current National Comprehensive Cancer Network (NCCN) posttreatment surveillance recommendations for human papillomavirus –associated oropharyngeal squamous cell carcinoma (HPV-associated OPSCC). Recognition of the favorable prognosis of HPV-associated OPSCC has led to the issue of whether the current NCCN-guided surveillance recommendations are appropriate for survivors of HPV-associated OPSCC. The goals of a regula r surveillance schedule are to identify cancer recurrence and sequela...
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
AbstractSquamous papillomas (SPs) of the head and neck are generally regarded as a human papillomavirus (HPV)-driven process, but reported rates of HPV detection vary dramatically. Moreover, they are generally considered a benign condition, but the detection of high risk HPV types is commonly reported. This latter finding is particularly disturbing to clinicians and their patients given the alarming rise of HPV-associated head and neck cancer. The capriciousness of HPV detection reflects in large part differences in methodologies. The purpose of this study was to review an institutional experience using a state of the art ...
Source: Head and Neck Pathology - Category: Pathology Source Type: research
In conclusion, HPV-DNA prevalence was significantly lower in our HNSCC patients than worldwide 32–36% estimates (p ≤ 0.001). Although infrequent, oropharyngeal cancer increased over years and showed 21% HPV-DNA positivity, which is close to the worldwide 36–46% estimates (p = 0.16). Besides age, smoking, tumor stage, and treatment, HPV/p16 status was an important determinant of patients’ survival. The HPV and/or p16 positivity patients had a better OS than HPV/p16 double-negative patients (p = 0.05). Thus, HPV/p16 status helps improve prognosis by distinguishing between the more favorab...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
This article provides a framework for decision making in the surgical and nonsurgical patient with head and neck cancer. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Seminars in Speech and Language - Category: Speech-Language Pathology Authors: Tags: Review Article Source Type: research
This article provides a framework for decision making in the surgical and nonsurgical patient with head and neck cancer. PMID: 31158905 [PubMed - in process]
Source: Seminars in Speech and Language - Category: Speech-Language Pathology Authors: Tags: Semin Speech Lang Source Type: research
Authors: Sahin AA, Gilligan TD, Caudell JJ Abstract Three experts discussed changes in the 8th edition of the AJCC Cancer Staging Manual and challenges regarding these changes for staging of breast cancer, testicular cancer, and head and neck cancer, respectively. In general, the staging changes for breast cancer and for human papillomavirus-positive oropharyngeal cancer were hailed as improvements, but the changes for testicular cancer were questioned as to their clinical relevance. Better studies are needed to improve staging for human papillomavirus-negative oropharyngeal cancer. PMID: 31117030 [PubMed - in process]
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
More News: Biology | Cancer | Cancer & Oncology | Chemotherapy | Erbitux | Genital Warts | Head and Neck Cancer | Human Papillomavirus (HPV) | Oropharyngeal Cancer | PET Scan | Physics | Radiation Therapy | Radiology | Toxicology