Two Years of Anti-Androgen Treatment Increases Other-Cause Mortality in Men Receiving Early Salvage Radiotherapy: A Secondary Analysis of the NRG Oncology/RTOG 9601 Randomized Phase III Trial

Salvage radiation therapy (SRT) is recommended for men with biochemically recurrent prostate cancer post-radical prostatectomy. RTOG 9601 was a randomized phase 3 clinical trial that demonstrated an overall survival (OS) benefit from the addition of long-term anti-androgen therapy to SRT. However, hormone therapy has well documented side effects and has been shown to increase cardiac event rates, and there remains no evidence of an OS benefit from hormone therapy for men treated with early SRT. Herein, we aim to determine if pre-SRT PSA can serve as both a prognostic and predictive biomarker of benefit or harm from hormone therapy.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research

Related Links:

Authors: Qian C, Liao CH, Tan BF, Chen YF, Dang BW, Chen JL, Liu CB Abstract Since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, "LncRNA PROX1-AS1 promotes proliferation, invasion, and migration in prostate cancer via targeting miR-647, by C. Qian, C.-H. Liao, B.-F. Tan, Y.-F. Chen, B.-W. Dang, J.-L. Chen, C.-B. Liu, published in Eur Rev Med Pharmacol Sci 2020; 24 (6): 2938-2944-DOI: 10.26355/eurrev_202003_20658-PMID: 32271411" has been withdrawn. The Publisher apologizes for any inconvenience t...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
When used in combination with abiraterone, the new drug showed activity in metastatic castration-resistant prostate cancer in the IPATential 150 trial.Medscape Medical News
Source: Medscape Urology Headlines - Category: Urology & Nephrology Tags: Hematology-Oncology News Source Type: news
Find out how the techniques and technology of the prostate biopsy have evolved in recent years -- and learn how these changes could impact the field of prostate cancer diagnosis.Translational Andrology and Urology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Urology Journal Article Source Type: news
Source: Anti-Cancer Agents in Medicinal Chemistry - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
In this study, feasibility was defined as the ability to distinguish between a positive and negative surgical margin, imaging within 45  min and low radiation exposure to staff.MethodsSix patients were included in this ongoing study. Following perioperative i.v. injection of ~  100 MBq68Ga-PSMA, the prostate was excised and immediately imaged ex vivo. Different acquisition protocols were tested, and hotspots on CLI images from the intact prostate were marked for comparison with histopathology.ResultsBy using an acquisition protocol with 150  s exposure time, 8 × 8 binning and a 550...
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Publication date: November 2020Source: Urology Case Reports, Volume 33Author(s): Michael-Abdo-Jefferson Billy El khoury, Marie Van Eycken, Thierry Roumeguère, Simone Albisinni
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 22 September 2020Source: European UrologyAuthor(s): Liselotte Boevé, Maarten C.C.M. Hulshof, Paul C.M.S. Verhagen, Jos W.R. Twisk, Wim P.J. Witjes, Peter de Vries, R. Jeroen A. van Moorselaar, George van Andel, André N. Vis
Source: European Urology - Category: Urology & Nephrology Source Type: research
To investigate fully balanced steady-state free precession (bSSFP) with optimized acquisition protocols for MRI-based post-implant quality assessment of low-dose-rate (LDR) prostate brachytherapy without an endorectal coil (ERC).
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Physics Contribution Source Type: research
AbstractPurposeProstate Cancer (PCa) is often considered to be an illness affecting older men, however the prevalence in younger men (
Source: Journal of Cancer Survivorship - Category: Cancer & Oncology Source Type: research
We examined the association between androgen deprivation therapy (ADT) use and the risk of mild cognitive impairment (MCI) among prostate cancer patients. METHODS: We included 241 cognitively unimpaired men, aged 70 to 90, with a history of prostate cancer before enrollment in the population-based Mayo Clinic Study of Aging. Using the Rochester Epidemiology Project medical records-linkage system, ADT use and length of exposure were abstracted. Follow-up visits occurred every 15 months and MCI diagnoses were made based on clinical consensus. Cox proportional hazards models, with age as the timescale, were used to examin...
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
More News: Biology | Cancer | Cancer & Oncology | Clinical Trials | Hormonal Therapy | Hormones | Physics | Prostate Cancer | Prostatectomy | Radiation Therapy | Radiology