Results of a Phase II Randomized Trial of Proton Beam Therapy vs Intensity Modulated Radiation Therapy in Esophageal Cancer

Proton Beam Therapy (PBT) is dosimetrically superior to Intensity Modulated Radiation Therapy (IMRT) in sparing critical organs in esophageal cancer (EC) patients (pts) treated with chemoradiation therapy (CRT). The extent to which better dosimetry translates into clinical benefit is not well established. We conducted a randomized trial to compare PBT to IMRT in terms of total toxicity burden (TTB) and progression free survival (PFS) time.

Source: International Journal of Radiation Oncology * Biology * Physics - September 18, 2019 Category: Radiology Authors: S.H. Lin, B. Hobbs, P. Thall, R.S. Tidwell, X. Wei, R.U. Komaki, J.Y. Chang, S.G. Chun, M.D. Jeter, S.M. Hahn, S.G. Swisher, J.A. Ajani, M.Blum Murphy, A.A. Vaporciyan, R. Mehran, A.C. Koong, S. Gandhi, W. Hofstetter, Z. Liao, R. Mohan Source Type: research