Tissue Iron Promotes Wound Repair via M2 Macrophage Polarization and the Chemokine (C-C Motif) Ligands 17 and 22

Macrophages are important for effective iron recycling and erythropoiesis, but they also play a crucial role in wound healing, orchestrating tissue repair. Recently, we demonstrated a significant accumulation of iron in healing wounds and a requirement of iron for effective repair. Herein, we sought to determine the influence of iron on macrophage function in the context of wound healing. Interestingly, wound macrophages extensively sequestered iron throughout healing, associated with a prohealing M2 phenotype.

Source: American Journal of Pathology - August 26, 2019 Category: Pathology Authors: Holly N. Wilkinson, Elizabeth R. Roberts, Amber R. Stafford, Kayleigh L. Banyard, Paolo Matteucci, Kimberly A. Mace, Matthew J. Hardman Source Type: research