Microvascular obstruction after primary percutaneous coronary intervention: pathogenesis, diagnosis and prognostic significance.

Microvascular obstruction after primary percutaneous coronary intervention: pathogenesis, diagnosis and prognostic significance. Curr Vasc Pharmacol. 2013 Mar 1;11(2):245-62 Authors: Niccoli G, Cosentino N, Minelli S, Cataneo L, Crea F Abstract The primary goal in reopening an infarct-related artery is the restoration of myocardial tissue-level perfusion. In a variable proportion of patients with ST-elevation myocardial infarction, however, microcirculatory impairment may persist after epicardial coronary artery recanalization. This phenomenon is known as microvascular obstruction (MVO). Ischemic injury, reperfusion injury, and distal embolization along with the individual response to each of these mechanisms are variably involved in the pathogenesis of MVO in the single patient. Importantly, MVO is associated with a worse prognosis both at short- and long-term follow-up. MVO can be assessed in the cath-lab by simple angiographic indexes, such as Thrombolysis in Myocardial Infarction grade score and Myocardial Blush Grade, or by invasive measures of coronary flow pattern. Imaging techniques, such as myocardial contrast echocardiography or cardiac magnetic resonance, and ST-segment resolution on standard electrocardiogram are used in the days following reperfusion with the patient in the coronary care unit. In this article, we review the available data regarding pathogenesis, diagnosis and the prognostic significance of MVO after primary percurtaneous coronary...
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research

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Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
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Source: Herz - Category: Cardiology Tags: Herz Source Type: research
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Source: Herz - Category: Cardiology Tags: Herz Source Type: research
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Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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Source: American Heart Journal - Category: Cardiology Source Type: research
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Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
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Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Liang Wudong, 62, died after treating patients in Wuhan amid signs that health workers are overwhelmed by the outbreakA doctor treating victims infected with the coronavirus in the Chinese city of Wuhan has died from the virus amid further signs that the local health system has been overwhelmed and that the outbreak is worsening.The 62-year-old doctor Liang Wudong died on Saturday morning, state media said, and it was also reported by the Chinese Global Times website that another doctor who had been treating patients in Wuhan died of a heart attack later in the day. It was not clear if Jiang Jijun, 51, had contracted the v...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak China Asia Pacific Science Health Source Type: news
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Source: Annals of Emergency Medicine - Category: Emergency Medicine Source Type: research
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Source: Interventional Neuroradiology - Category: Radiology Tags: Interv Neuroradiol Source Type: research
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