Controversies on HDL: Should it Be a Target Biomarker in Patients With Lipid Disorders?

Controversies on HDL: Should it Be a Target Biomarker in Patients With Lipid Disorders? Curr Vasc Pharmacol. 2013 Apr 25; Authors: Nicholls S Abstract LDL cholesterol lowering with statins have had a profound impact on cardiovascular (CV) event rates and accordingly have become an integral component of strategies designed to reduce CV risk. The finding of a residual clinical risk, despite LDL cholesterol lowering, supports the need to develop additional therapeutic strategies for CV prevention. Numerous lines of evidence suggest that targeting the protective properties of HDL may be beneficial. Disappointing results from recent reports of HDL genetics and raising agents and clinical events has fueled considerable debate as towhether attempts to target HDL will be of clinical benefit or futility. PMID: 23627977 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research

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A second phase 3 study has shown impressive reductions in LDL on top of statins with this novel agent given just twice a year.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Source Type: news
In this study both experimental and theoretical methods were used to get insight into photophysical and photochemical properties of PTV with respect to its primary photochemistry. The PTV photodegradation quantum yield value was determined to be ะค = 0.011 (±0.002). PTV was found to undergo an intersystem crossing, however 3PTV* was formed with a low efficiency due partially to fluorescent properties exhibited by the statin. The lifetime of the excited singlet 1PTV* was calculated to be about 130 (±20) ps. 3PTV* was shown to be not involved in the formation of PTV primary photoproduct. Both PTV ...
Source: Journal of Photochemistry and Photobiology A: Chemistry - Category: Chemistry Source Type: research
Authors: Infante T, Viscovo LD, Rimini ML, Padula S, Caso P, Napoli C Abstract Early identification of coronary atherosclerotic pathogenic mechanisms is useful for predicting the risk of coronary heart disease (CHD) and future cardiac events. Epigenome changes may clarify a significant fraction of this "missing hereditability", thus offering novel potential biomarkers for prevention and care of CHD. The rapidly growing disciplines of systems biology and network science are now poised to meet the fields of precision medicine and personalized therapy. Network medicine integrates standard clinical recording ...
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
This study aimed to investigate if statin use in cancer survivors was inversely associated with all-cause mortality.Methods and ResultsData from the 2002 to 2015 National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) were used. The Kaplan-Meier estimator was used to estimate the survival function according to statin usage. Cox proportional hazards regression models were adopted after stepwise adjustment for potential confounders to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality. The median follow-up duration was 10.0 years. Statin users had a higher percent...
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Authors: Schlesinger A, Weiss A, Nenaydenko O, Koren-Morag N, Adunsky A, Beloosesky Y Abstract BACKGROUND: Statins and selective serotonin reuptake inhibitors (SSRIs) have beneficial effects on health outcomes in the general population. Their effect on survival in debilitated nursing home residents is unknown. OBJECTIVES: To assess the relationships between statins, SSRIs, and survival of nursing home residents. METHODS: Baseline patient characteristics, including chronic medications, were recorded. The association of 5-year survival with different variables was analyzed. A sub-group analysis of survival wa...
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
Anagliptin, a dipeptidyl peptidase-4 inhibitor, is reported to reduce the level of low-density lipoprotein cholesterol (LDL-C). The underlying mechanism of this effect and effect on lipid metabolism however re...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research
ConclusionBoth neurologic and medical complications were common in majority of stroke patients. But the management protocol for stroke patients was sub-optimal and lagging behind the recommended guidelines due to lack of skilled personnel, appropriate treatment and diagnostic agents. The clinical team involved in the care of stroke patients should make preparations to take preventive measures that will save a lot of lives.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
Condition:   Hypercholesterolemia Intervention:   Drug: CIVI 007 Sponsor:   Civi Biopharma, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractNo studies evaluating the association between statins and outcomes of patients with seasonal influenza have been performed since the 2007 –2008 and the 2009 pandemic H1N1 influenza seasons. All consecutive hospitalized patients between October 2017 and April 2018, diagnosed with laboratory-confirmed influenza A and B virus, were included. Patients were divided into two groups: statin and non-statin users. Outcomes were 30- and 90-da y mortality, complications (pneumonia, myocarditis, encephalitis, intensive care unit (ICU) transfer, mechanical ventilation, vasopressor support), length of hospital stay, and re...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
A 64-year-old woman with a significant medical history sees her cardiologist for a routine follow-up after a second MI. How do you minimize her risk for future ASCVD events?American College of Cardiology &Medscape
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology Clinical Case Source Type: news
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