Platelet function and activation markers in primary hypercholesterolemia treated with PCSK9 monoclonal antibody: a 12-month follow-up

In the association between hypercholesterolemia (HC) and thrombotic risk platelet hyper-reactivity plays an important role. The inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) to reduce plasma LDL ‐cholesterol merges as effective therapeutic strategy to prevent cardiovascular (CV) events. Aim of this study was to verify whether a treatment up to 12 months with the monoclonal antibodies (mAbs) anti-PCSK9 influences platelet function in primary HC.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research

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Publication date: Available online 21 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Hiart Navarro-Imaz, Begoña Ochoa, Itsaso García-Arcos, María José Martínez, Yolanda Chico, Olatz Fresnedo, Yuri RuedaAbstractStaphylococcal nuclease and Tudor domain containing 1 (SND1) is an evolutionarily conserved protein present in eukaryotic cells from protozoa to mammals. SND1 has gained importance because it is overexpressed in aggressive cancer cells and diverse primary tumors. Indeed, it is regarded as a marker of cancer malignity. A broad...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - Category: Lipidology Source Type: research
This study was aimed to evaluate association of vitamin D receptor gene polymorphisms with susceptibility to T2DM.Subjects and methods: One hundred T2DM Saudi male patients were included in this study and one hundred healthy Saudi men were used as control. For each individual, fasting blood glucose, cholesterol, HDL-C, LDL-C, HbA1c, insulin and 25-(OH) vitamin D were measured. In addition,Apal, BsmI and TaqI genotypes were performed for each subject. Data was analyzed by SPSS version 16, using Spearman's rho and ANOVA tests.Results: There was significant inverse correlation between 25-(OH) vitamin D level and T2DM (p
Source: African Health Sciences - Category: African Health Source Type: research
Conclusion: There was a high prevalence of MetS and abnormal ECG among the studied population. Abnormal ECG findings were more common in men with no differential association in people with or without MetS. However, a significant association existed between certain components of MetS and ECG abnormalities in men only. Male gender and HDLc were independent predictors of ECG Abnormalities.Keyword: Electrocardiography, metabolic syndrome, africans.
Source: African Health Sciences - Category: African Health Source Type: research
AbstractPurpose of ReviewReduction of serum low-density lipoprotein cholesterol (LDL-C) levels by statins, ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors has been shown to significantly reduce cardiovascular events risk. However, fasting and postprandial hypertriglyceridemia as well as reduced high-density lipoprotein cholesterol (HDL-C) remain as residual risk factors of atherosclerotic cardiovascular diseases (ASCVD). To treat patients with hypertriglyceridemia and/or low HDL-C, drugs such as fibrates, nicotinic acids, and n-3 polyunsaturated fatty acids have been used. However, fibrates w...
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research
Authors: Wu CC, Chang CS, Hsu CC, Wang CP, Tsai IT, Lu YC, Houng JY, Chang CC, Chung FM, Lee YJ, Hung WC Abstract Low-circulating levels of adiponectin (ADPN) are associated with obesity, diabetes mellitus, and coronary artery disease. On the contrary, some studies have demonstrated a link between relatively high levels of plasma ADPN and heart failure, atrial fibrillation, and adverse outcome. However, little is known about the relationship between ADPN level and prolonged QT interval. The aim of this study was to investigate the association between plasma ADPN levels and prolonged QT interval in patients with sta...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Today's research materials are representative of numerous initiatives aiming to produce taxonomies of the biochemistry of aging, to catalog the observed variations. Yet, with the exception of a very small number of unlucky souls bearing rare harmful mutations, we all age for the same underlying reasons. The same processes of metabolism produce the same forms of cell and tissue damage, leading to the same downstream dysfunctions and the same ultimately fatal age-related conditions. Yes, there is some variation in outcome. For all that aging is a universally similar process of multiple interacting forms of damage, some porti...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
ConclusionsAppetitive behaviors at 7-years are associated with cardiometabolic risk at age 10. While ’food avoidant’ behaviors protect against cardiometabolic risk and ‘food approach’ behaviors increase cardiometabolic risk, these associations are largely dependent of child´s adiposity.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: April 2020Source: Biomedicine &Pharmacotherapy, Volume 124Author(s): Napatara Tirawanchai, Kanchana Kengkoom, Duangnate Isarangkul, Jankana Burana-osot, Tapanee Kanjanapruthipong, Surachai Chantip, Panadda Phattanawasin, Uthai Sotanaphun, Sumate AmpawongAbstractKaffir lime leaves and the rhizomes of galangal and lemongrass are the main ingredients in several Thai foods with desirable medicinal effects. Based on their beneficial activities, this study aimed to indicate the chemical properties and in vivo efficacy of a combination of the herbs at a 1:2:1 ratio in a water extract form. Its volatile const...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
High levels of plaque calcification on coronary CT angiography (CCTA) scans...Read more on AuntMinnie.comRelated Reading: CCTA, functional tests stratify heart disease risk by age Onsite FFR-CT tops CCTA in detecting coronary stenosis CCTA reveals statins may lower mortality in low-risk CAD CCTA biomarker may predict mortality from heart disease CCTA biomarker spots high-risk plaques in heart disease
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Publication date: Available online 22 January 2020Source: Clinica Chimica ActaAuthor(s): Xin Su, Daoquan PengAbstractDyslipidemia, characterized by increased plasma levels of low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), triglyceride (TG), and reduced plasma levels of high-density lipoprotein cholesterol (HDL-C), is confirmed as a hallmark of obesity and cardiovascular diseases (CVD), posing serious risks to the future health of humans. Thus, it is important to understand the molecular metabolism of dyslipidemia, which could help reduce the morbidity and mortality of obesit...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
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