The Prostaglandin Agonist Beraprost Aggravates Doxorubicin-Mediated Apoptosis by Increasing iNOS Expression in Cardiomyocytes.

In conclusion, we demonstrated that BPS or adv-COX-1/PGIS increases PGI2 levels through iNOS expression and peroxynitrite production, via CREB protein phosphorylation; thereby aggravating DOX-mediated cardiotoxicity. PMID: 23628005 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/23628005?dopt=Abstract

Source: Current Vascular Pharmacology - April 29, 2013 Category: Drugs & Pharmacology Authors: Lian WS, Chiou HC, Lin H, Chen JJ, Cheng CF Tags: Curr Vasc Pharmacol Source Type: research