Effect of a New Class of Compounds of the Group of Substituted 5r1, 6h2-1,3,4-Thiadiazine-2-Amines on the Inflammatory and Cytokine Response in Experimental Myocardial Infarction.

This study investigated the effects of the L-17 compound of the group of substituted 5R1, 6H2-1,3,4-thiadiazine-2-amines on the immune response and the plasma level of circulating cytokines in acute myocardial infarction (MI) in rats. The study was based upon experimental work which demonstrated the role of local and systemic inflammatory reactions in MI. Acute MI in rats was induced by left coronary artery coagulation. Histological study of the myocardium sections has been carried out at the 1st and 7th days of the experimental myocardial infarction. Serum activity of creatine kinase (CK), aspartate aminotransferase (AST), isoenzymes 1 and 2 and lactate dehydrogenase (LDH1-2) were investigated at days 1 and 7. ELISA analysis for plasma cytokine levels was performed using commercially available test kits following the manufacturer's instructions. Biochemical analysis in animals with the administration of the L-17 compound after MI showed that the AST and CK levels at days 5 and 7 of experiments did not differ significantly from the values of intact animals. In animals of the group with MI without the administration of the L-17 compound, the IL-1 level 8 times and the TNF level 7.8 times exceeded the normal indicators, while the use of L-17 compound in the therapy resulted in only 1.8 times increase of IL-1 level and 4.7 times increase of TNF level in comparison with the norm. Thus, the introduction of L-17 compound in case of experimental MI delays exudative/alternative pha...
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research

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Importance: Hospitals that serve poorer populations have higher readmission rates. It is unknown whether these hospitals effectively lowered readmission rates in response to the Hospital Readmissions Reduction Program (HRRP). Objective: To compare pre-post differences in readmission rates among hospitals with different proportion of dual-eligible patients both generally and among the most highly penalized (ie, low performing) hospitals. Design: Retrospective cohort study using piecewise linear model with estimated hospital-level risk-standardized readmission rates (RSRRs) as the dependent variable and a change poin...
Source: Medical Care - Category: Health Management Tags: Original Articles Source Type: research
Publication date: Available online 12 November 2019Source: Canadian Journal of CardiologyAuthor(s): Mohammed Shurrab, Asaf Danon, Sami Alnasser, Benedict Glover, Anna Kaoutskaia, Mark Henderson, David Newman, Eugene Crystal, Dennis KoAbstractBackgroundThe choice of antithrombotic therapy for atrial fibrillation (AF) patients who have an acute coronary syndrome (ACS) or have undergone percutaneous coronary intervention (PCI) is challenging. We aimed to assess outcomes between dual antithrombotic therapy with DOACs plus an antiplatelet agent (Dual therapy) in comparison to warfarin plus two antiplatelet agents (Triple therap...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
ConclusionsAlthough most high-risk patients with T2D and CV disease were on lipid-lowering therapy, only 1:3 had LDL-C 
Source: American Heart Journal - Category: Cardiology Source Type: research
Authors: Pepera G, Xanthos Ε, Lilios A, Xanthos T Abstract High quality cardiopulmonary resuscitation (CPR) is crucial for influencing survival from cardiac arrest. Healthcare professionals are expected to know how to perform CPR as they may encounter emergency situations during their work. Physiotherapists, who use exercise as a therapeutic approach, should have good knowledge and skills in CPR not only to cope with possible adverse cardiac events during exercise but also because a widespread CPR application and early defibrillation can greatly reduce mortality due to heart attack. The aim of this study is...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Obesity, insulin resistance, dyslipidemia, and hypertension are fundamental clinical manifestations of the metabolic syndrome. Studies over the last few decades have implicated chronic inflammation and microvascular remodeling in the development of obesity and insulin resistance. Newer observations, however, suggest that dysregulation of the lymphatic system underlies the development of the metabolic syndrome. This review summarizes recent advances in the field, discussing how lymphatic abnormality promotes obesity and insulin resistance, and, conversely, how the metabolic syndrome impairs lymphatic function. We also discu...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
People who suffered a heart health scare -- a heart attack, heart failure or a dangerously erratic heart rhythm -- had a more than sevenfold increased risk for subsequently developing cancer, compared to those with healthy tickers, researchers said.
Source: WebMD Health - Category: Consumer Health News Source Type: news
ConclusionsAn increase in diagnostic and therapeutic procedures was reported in 2018, particularly in primary percutaneous coronary interventions. The use of the radial approach and complex procedures also increased. The number of structural procedures rose significantly, following the trend seen in recent years.ResumenIntroducción y objetivosLa Sección de Hemodinámica y Cardiología Intervencionista presenta su informe anual con los datos del registro de actividad correspondiente a 2018.MétodosLos centros españoles con laboratorio de hemodinámica proporcionan sus datos volun...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
HEART attack is considered a serious medical emergency and the risk of one happening is increased during winter. So how can you prevent the life-threatening condition? Making sure your home is the right temperature is the advice from TV doctor Dr Zoe Williams.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
WEDNESDAY, Nov. 13, 2019 -- Here's some worrisome news for folks who manage to survive a heart attack: New research suggests they might be far more vulnerable to developing cancer down the road. People who suffered a heart health scare -- a heart...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN01679A, PaperKyu Shik Eom, Yijae Lee, Hye Won Seo, Ji Yoon Kang, Joon S. Shim, Soo Hyun Lee An excessive cholesterol level can lead to cardiovascular diseases, such as stroke, hypertension, and myocardial infarction. A non-invasive, painless method of determining the cholesterol in the blood would improve the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
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