Role of Innate Immune System in Inflammation and Cardiac Remodeling After Myocardial Infarction.

Role of Innate Immune System in Inflammation and Cardiac Remodeling After Myocardial Infarction. Curr Vasc Pharmacol. 2013 Apr 29; Authors: Takahashi M Abstract The innate immune system is well recognized as the first line defense of foreign pathogens; however, it can also recognize endogenous signals released from injured tissues and induce sterile inflammation. Toll-like receptors (TLRs) and Nod-like receptors (NLRs) have been identified as its receptors, and they have been shown to play a key role in the disease processes of sterile inflammation, including myocardial infarction (MI). In particular, NLRs are the key components of the caspase-1 activating platform known as the "inflammasome" which produces the potent proinflammatory cytokine interleukin-1β. The current article reviews the role of the innate immune system, especially TLRs and inflammasomes, in the pathophysiology of MI. PMID: 23628011 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research

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