Cells of myeloid origin partly mediate the association between psoriasis severity and coronary plaque

Psoriasis, a chronic inflammatory skin disease is associated with heightened immune activation, accelerated cardiovascular (CV) risk as well as increased acute coronary syndromes, most evident in young adults (Gelfand et al., 2006). This inflammatory skin disease confers an independent risk for myocardial infarction (MI) beyond traditional CV risk factors (Mehta et al., 2010) and on average leads to a decreased lifespan of five years (Gelfand et al., 2006). One explanation is the susceptibility of psoriasis patients to develop unstable, lipid-rich non-calcified coronary plaques (NCB) that are vulnerable to rupture (Lerman et al., 2017).

Source: Journal of Investigative Dermatology - September 16, 2019 Category: Dermatology Authors: Heather L. Teague, Milena Aksentijevich, Elena Stansky, Joanna I. Silverman, Nevin J. Varghese, Amit K. Dey, Youssef Elnabawi, Aditya Goyal, Pradeep K. Dagur, Marcus Y. Chen, J. Philip McCoy, Martin P. Playford, Christopher Hourigan, Joel M. Gelfand, Neha Tags: Letters to the Editor Source Type: research