Changes In Global Electrical Heterogeneity Associated With Dofetilide, Quinidine, Ranolazine, And Verapamil

ECG markers of antiarrhythmic drug (AAD) activity could be used to optimize efficacy and minimize toxicity. Vectorcardiographic (VCG) global electrical heterogeneity (GEH) is associated with ventricular arrhythmias and sudden death, but it is unclear how GEH measurements change in response to AADs.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research

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DiscussionGiven the multiorgan system potential adverse side effects of prednisone, proving noninferiority of an alternate regimen would be sufficient to make the alternative compare favorably to standard dose steroids. This is the first ever clinical trial in cardiac sarcoidosis and thus in addition to the listed goals of the trial, we will also establish a multi-center, multinational cardiac sarcoidosis clinical trials network. Such a collaborative infrastructure will enable a new era of high quality data to guide physicians when treating cardiac sarcoidosis patients.
Source: American Heart Journal - Category: Cardiology Source Type: research
Authors: Zeng L, Zhang Z, Wang X, Tu S, Ye F Abstract BACKGROUND The aim of this study was to investigate the correlations of circadian rhythm disorder of blood pressure with arrhythmia and target organ damage in hypertensive patients. MATERIAL AND METHODS A total of 198 patients admitted and treated in our hospital from May 2018 to April 2019 were selected to receive 24-h ambulatory blood pressure monitoring. The nighttime blood pressure decrease rate is 0-10% in people with normal circadian rhythm of blood pressure. In the present study, we divided patients into a normal circadian rhythm group (normal circadian r...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Mayr F, Vieider C, Temml V, Stuppner H, Schuster D Abstract Interference with the hERG potassium ion channel may cause cardiac arrhythmia and can even lead to death. Over the last few decades, several drugs, already on the market, and many more investigational drugs in various development stages, have had to be discontinued because of their hERG-associated toxicity. To recognize potential hERG activity in the early stages of drug development, a wide array of computational tools, based on different principles, such as 3D QSAR, 2D and 3D similarity, and machine learning, have been developed and are reviewed ...
Source: Progress in the chemistry of organic natural products - Category: Chemistry Tags: Prog Chem Org Nat Prod Source Type: research
Publication date: Available online 7 October 2019Source: Pathology - Research and PracticeAuthor(s): Dominik Gross, Christina LaursAbstractThe Jewish pathologist Carl Julius Rothberger (1871–1945) is undoubtedly one of the most important representatives of his field. His studies on atrial fibrillation, the bundle branch block and arrhythmia perpetua in particular secured him a place in medical history. Rothberger also gave the name to an agar used to prove the neutral red reduction of salmonella (Rothberger-Scheffler agar).While Rothberger’s name is well known in pathology, his biography and his experiences of ...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
ConclusionsThese findings provided strong evidences that TGD intervention ameliorated interstitial fibrosis, myocyte hypertrophy and gap junction expression in the IBZ, attenuated left ventricular remodeling and dysfunction, and reduced vulnerability to tachyarrhythmia. TGD inhibited IBZ remodeling by its inhibition effect on myofibroblasts differentiation.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 16 October 2019Source: Canadian Journal of CardiologyAuthor(s): Sattler Katherine, El-Battrawy Ibrahim, Gietzen Thorsten, Kummer Marvin, Lang Siegfried, Zhou Xiao-bo, Behnes Michael, Borggrefe Martin, Akin IbrahimAbstractBackgroundCardiogenic shock (1) is a severe complication of myocardial infarction (MI) or of takotsubo syndrome. For both diseases, CS is related to a worse long term outcome. Outcome of CS has not been studied in a direct comparison of MI patients and TTS patients.Methods and ResultsMortality and cardiovascular complications were compared in patients presenting with CS b...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
ConclusionThe IECF is simple, particularly at reoperations, in borderline patients and those needing concomitant intracardiac procedures. Early results are promising. These patients need constant surveillance.
Source: Indian Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable nonselective cation channel in the plasma membrane that belongs to the transient receptor potential (TRP) channel superfamily. Recent studies have suggested that the TRPA1 channel plays an essential role in the development and progression of several cardiovascular conditions, such as atherosclerosis, heart failure, myocardial ischemia–reperfusion injury, myocardial fibrosis, arrhythmia, vasodilation, and hypertension. Activation of the TRPA1 channel has a protective effect against the development of atherosclerosis. Furthermore, TRPA1 c...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: Collectively, these findings suggest that the increased ventricular arrhythmia susceptibility of type 2 diabetic mouse hearts is due to dysregulation of the sympathetic ventricular control. PMID: 31625779 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
In this edition of the Journal, Li et al report on patients with dilated cardiomyopathy (DCM) and arrhythmias (DCM-A) compared with patients with DCM with no arrhythmias (DCM-NA), with the explicit intent to identify the genetic causes of arrhythmias in DCM.1 Using whole-exome sequencing and high-depth targeted next-generation sequencing followed by Sanger sequencing of all causative variants to eliminate false-positive results, eight specific DCM-A pedigrees and two separate cohorts of 1232 consecutive unrelated sporadic DCM-NA patients were studied (550 patients in discovery cohort, 682 patients in replication cohort).
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research
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