Chronic fatigue syndrome: identification of transcription factor (TFs) associated with gene expression for drug signature prediction

This study also found that small-molecules BRD-A94756469, S1205, Sotalol hydrochloride, methylandrostenediol and BRD-A94756469 can potentiall y reverse gene expression in CFS disease.
Source: Network Modeling Analysis in Health Informatics and Bioinformatics - Category: Bioinformatics Source Type: research

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BACKGROUND: Falls and fall-related injuries remain an ongoing and serious health problem in older adults. Many clinical and environmental factors have been implicated in falls and recurrent falls, including sleep disturbances, sensory deficits, balance pro...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
This study tests the factorial validity of a brief measure of obesity-related parenting and measurement invariance of the English and Spanish versions of the scale, as well as among mothers and fathers.MethodsParents of children enrolled in Head Start (n=578; 500 mothers and 78 fathers) completed a brief survey of food (7 items), physical activity (5 items), and sleep parenting (3 items) in fall of 2017 and 2018. Scale items were drawn from existing measures and the evidence base, initially drafted in English, and then translated to Spanish. One parent per family completed the scale independently in English (n=448) or Span...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
HOW TO sleep: Many people in the UK struggle to get the required amount of sleep at night to ensure they are fully functioning the next day. While the cost of sleepless nights is grave, addressing sleep loss can be surprisingly simple and evidence suggests a particular drink may induce sleep.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Condition:   Sleep Interventions:   Other: Acoustic stimulation;   Other: SHAM acoustic stimulation Sponsor:   Caroline Lustenberger Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Episodic Migraine Intervention:   Device: TheraNova Migraine Treatment System Sponsor:   Theranova, L.L.C. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Cannabidiol (CBD) oil and other products containing CBD are being touted as a natural, organic remedy for a wide range of women’s health concerns. Sellers of these products make many claims: CBD has calming effects on sleep, mood, and anxiety; eases hot flashes and improves bone density by balancing hormonal changes of menopause; and has anti-inflammatory properties that clear skin, cure acne, and calm rosacea. It’s promoted for PMS symptoms like bloating and mood swings. And CBD-infused lubricants claim to boost arousal and enjoyment of sex. So, how much of this is true? First, what is CBD? CBD is a major ingr...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Complementary and alternative medicine Drugs and Supplements Health Marijuana Women's Health Source Type: blogs
PROSTATE cancer is the most common type of cancer in men in the UK, and because there ’s currently no cure, it’s important to be aware of the risks for developing the disease. According to studies, how you sleep can increase your risk of prostate cancer.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Sleep quality varies widely across individuals, especially during normal aging, with impaired sleep contributing to deficits in cognition and emotional regulation. Sleep can also be impacted by a variety of adverse events, including childhood adversity. He...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Background Chronic fatigue syndrome is a common condition characterized by severe fatigue with post-exertional malaise, impaired cognitive ability, poor sleep quality, muscle pain, multi-joint pain, tender lymph nodes, sore throat or headache. Its defining symptom, fatigue is common to several diseases. Areas of agreement Research has established a broad picture of impairment across autonomic, endocrine and inflammatory systems though progress seems to have reached an impasse. Areas of controversy The absence of a clear consensus view of the pathophysiology of fatigue suggests the need to switch from a focus on abnormali...
Source: British Medical Bulletin - Category: Journals (General) Authors: Tags: Geriatric Medicine Articles Source Type: research
by Sanjay K. Shukla, Dane Cook, Jacob Meyer, Suzanne D. Vernon, Thao Le, Derek Clevidence, Charles E. Robertson, Steven J. Schrodi, Steven Yale, Daniel N. Frank Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease characterized by intense and debilitating fatigue not due to physical activity that has persisted for at least 6 months, post-exertional malaise, unrefreshing sleep, and accompanied by a number of secondary symptoms, including sore throat, memory and concentration impairment, headache, and muscle/joint pain. In patients with post-exertional malaise, significant worsening of symptoms occurs fo...
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
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