Glucose-Responsive Capsules Based on (Phenylboronic-modified Poly(Lysine)/Alginate) System

Publication date: November 2019Source: European Polymer Journal, Volume 120Author(s): Ones Mansour, Taleen Peker, Sena Hamadi, Sabrina BelbekhoucheAbstractDeveloping “smart” systems that respond to chemical stimuli is of major interest. The physico-chemical properties of such a system would enable it to detect and respond to changes in the concentrations of targeted molecules. Saccharides are one member of a challenging class of chemical stimuli that are particularly important with respect to both medical applications and industrial processes. In this context, a new glucose-responsive, multilayer system based on electrostatic interaction has been created via the layer-by-layer deposition of biopolymers. The studied polymers are poly(lysine) derivatives and alginate and are used as polycation and polyanion respectively. The system detected glucose at levels approximating 0.5 g.L−1 at which point the chemical modification of poly(lysine) with phenylboronic acid groups (known to form complexes with diol derivatives) occured. Herein, we have shown, using wetting contact and quartz crystal microbalance (QCM) measurements, that the poly(lysine) derivatives self-assemble with alginate through the formation of electrostatic bonding throughout the layer-by-layer assembly. QCM measurement revealed that introducing boronic acid moieties inside a macromolecular chain leads to glucose-responsiveness. This strategy was then extended to the fabrication of responsive part...
Source: European Polymer Journal - Category: Chemistry Source Type: research

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Total external ophthalmoplegia: First clinical manifestation of Sjögren's syndrome. Strabismus. 2019 Sep 06;:1-5 Authors: Singh A, Mahesh M, Agrawal A, Kumar N, Verma R, Mittal SK, Kumar B Abstract Sjögren's syndrome (SS) is an autoimmune disease causing destruction of the exocrine glands secondary to lymphocytic infiltration. Common clinical symptoms of SS are xerostomia, xerophthalmia, myalgia, arthritis, and vasculitis. Neurological symptoms may precede the diagnosis of SS by up to 2 years in about 80% of patients. A 28-year-old female presented to us with complaints of horizontal and vert...
Source: Strabismus - Category: Research Tags: Strabismus Source Type: research
Abstract Orbital apex syndrome (OAS) manifests as multiple cranial nerve palsies caused by an abnormal nerve response to inflammation or other processes. Central diabetes insipidus (CDI) is characterized by deficient synthesis or secretion of antidiuretic hormone. A 62-year-old woman underwent myringotomy for otitis media with effusion. Two months after the procedure, symptoms of hearing loss had not improved, and she underwent left tympanoplasty and mastoidectomy. After surgery, she presented with left ocular pain and visual loss. Neurologic examination revealed ptosis, total ophthalmoplegia, and a relative affer...
Source: Journal of Nippon Medical School - Category: Universities & Medical Training Authors: Tags: J Nippon Med Sch Source Type: research
Discussion Bardet-Biedl syndrome (BBS) is a rare disorder. It is usually considered an autosomal recessive disorder but there is significant intra-familial variability. There are multiple genes (~20 currently) involved and it is believed that the phenotypic variability is due to “…differences in the total mutational load across different BBS associated genes….” It is a ciliopathy where mutation changes in proteins in the cilias causes problems in the cilia’s functioning particularly signaling. Cilia are important in signaling to maintain tissue and cellular homeostasis. Obviously screening o...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Publication date: Available online 21 June 2019Source: Personalized Medicine UniverseAuthor(s): Kasumi Satoh, Tomoki Furuya, Manabu Okuyama, Hajime NakaeAbstractA 40-year-old man was admitted to the hospital with multiple injuries, including head injury and his laboratory results were significant for sodium abnormalities. Initially, hypernatremia was from increased sodium intake. Subsequently, hyponatremia developed that was unresponsive to sodium supplementation. Syndrome of inappropriate antidiuretic hormone secretion or cerebral salt wasting syndrome was suspected. Additional tests suggested post-traumatic hypopituitari...
Source: Personalized Medicine Universe - Category: Drugs & Pharmacology Source Type: research
Rationale: X-linked nephrogenic diabetes insipidus (NDI) is a rare inherited disease, and is characterized by renal resistance to arginine vasopressin (AVP). Its diagnosis can be clinically challenging. The application of molecular genetic analysis can provide a rapid and definitive diagnosis. Patient concerns: A 75-year-old woman presented with recurrent nausea and vomiting was admitted to the Department of Gastroenterology. The patient had a strong family history of polydipsia and polyuria. Sequencing analysis of the antidiuretic hormone arginine vasopressin receptor 2 (AVPR2) revealed the novel missense mutation p....
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
CONCLUSIONSurgeons should be aware of the persistent renal defects caused by long term lithium use and development of nephrogenic diabetes insipidus even years after medication cessation.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Date: March 25, 2019 Issue #:  1568Summary:  The FDA has approved a sublingual tablet (Nocdurna– Ferring) and a nasal spray (Noctiva– Avadel) formulation of desmopressin acetate for treatment of nocturia due to nocturnal polyuria in adults who wake up ≥2 times per night to void.Nocdurna andNoctiva are the first two products to be approved in the US for this indication. Higher-strength nasal spray and oral tablet formulations of desmopressin (DDAVP, and others) have been available for years for treatment of diabetes insipidus and primary nocturnal enuresis (bedwetting in children)...
Source: The Medical Letter - Category: Drugs & Pharmacology Authors: Source Type: research
CONCLUSION: Hemodialysis patients are likely to develop lacrimal hyposecretion mostly because of comorbities. It is therefore important to systematically evaluate lacrimal secretion in these patients. PMID: 30857803 [PubMed - as supplied by publisher]
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
CONCLUSION: After a meat meal, the peak GFR response is delayed in CDI patients suggesting that VP might indirectly affect tubule-glomerular feedback. PMID: 30778919 [PubMed - as supplied by publisher]
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
AbstractPurposeTo provide a practical overview of the management of the potential organ donor in the intensive care unit.MethodsSeven areas of donor management were considered for this review: hemodynamic management; fluids and electrolytes; respiratory management; endocrine management; temperature management; anaemia and coagulation; infection management. For each subchapter, a narrative review was conducted.Results and conclusionsMost elements in the current recommendations and guidelines are based on pathophysiological reasoning, epidemiological observations, or extrapolations from general ICU management strategies, and...
Source: Intensive Care Medicine - Category: Intensive Care Source Type: research
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