Structural basis for transcription activation by Crl through tethering of {sigma}S and RNA polymerase [Biochemistry]

In bacteria, a primary σ-factor associates with the core RNA polymerase (RNAP) to control most transcription initiation, while alternative σ-factors are used to coordinate expression of additional regulons in response to environmental conditions. Many alternative σ-factors are negatively regulated by anti–σ-factors. In Escherichia coli, Salmonella enterica, and many other γ-proteobacteria,...

http://www.pnas.org/content/116/38/18923.short?rss=1

Source: Proceedings of the National Academy of Sciences - September 16, 2019 Category: Science Authors: Alexis Jaramillo Cartagena, Amy B. Banta, Nikhil Sathyan, Wilma Ross, Richard L. Gourse, Elizabeth A. Campbell, Seth A. Darst Tags: Biological Sciences Source Type: research