Experience in multicatheter interstitial high-dose-rate breast brachytherapy: dose-volume histogram analysis of the first results.
Conclusions: This study is the first stage of the dosimetric evaluation of a new method. The analysis allows treating complex localizations of the breast cancer, for example, in a close position to the skin or ribs. In order to minimize the toxic effects, it is necessary to consider patient selection, catheter administration, and dose optimization. PMID: 31523236 [PubMed]
Publication date: Available online 5 December 2019Source: The LancetAuthor(s): Frank A Vicini, Reena S Cecchini, Julia R White, Douglas W Arthur, Thomas B Julian, Rachel A Rabinovitch, Robert R Kuske, Patricia A Ganz, David S Parda, Michael F Scheier, Kathryn A Winter, Soonmyung Paik, Henry M Kuerer, Laura A Vallow, Lori J Pierce, Eleftherios P Mamounas, Beryl McCormick, Joseph P Costantino, Harry D Bear, Isabelle GermainSummaryBackgroundWhole-breast irradiation after breast-conserving surgery for patients with early-stage breast cancer decreases ipsilateral breast-tumour recurrence (IBTR), yielding comparable results to m...
ConclusionBased on the available findings, the DEGRO breast cancer expert panel recommends the use of DIBH as the best heart-sparing technique. Nonetheless, depending on the treatment volume and localization, other techniques may be employed or combined with DIBH when appropriate.
This report details our experience using accelerated partial breast irradiation (APBI) as a component of salvage breast conserving treatment.
To compare radiation lung dose in patients with early-stage breast cancer treated with lumpectomy and intraoperative radiation therapy with CT-guided HDR brachytherapy (Precision Breast IORT; PB-IORT) and those treated with whole breast irradiation (WBI-DIBH) or partial breast irradiation (PB-DIBH) with deep inspiratory breath hold.
Accelerated Partial Breast Irradiation or APBI is one of the techniques that is being used in the early stage breast cancers. This treatment technique includes external beam therapy or SAVI / balloon Applicators brachytherapy. In the later technique, applicators like SAVI or Balloons (CONTURA or Best Balloon) are used after lumpectomy to treat the patient. In some cases, a patient may have Bi-Lateral Breast cancer. At our center, we have treated two patients with SAVI devices in both the breasts.
ConclusionIn case of 2ndIBTE, GAC could be used as a decision helping tool to discuss conservative or radical treatment options. Patient information remains crucial in order to accurately define the salvage therapy modalities.
Older ( ≥67 years) breast cancer survivors diagnosed in 2009 and treated with 1 of 5 local-therapy options [lumpectomy plus whole breast irradiation, brachytherapy, or endocrine therapy (Lump+WBI, Lump+Brachy, or Lump-alone) or mastectomy -/+ radiation (Mast-alone or Mast+RT)] were surveyed to examine the ir local-therapy treatment-related decisional regret 6-years after diagnosis. Local-therapy regret afflicted nearly one-quarter of our cohort and was associated with black race, less education, and more extensive nodal dissection but not breast surgery.
Publication date: September–October 2018Source: Reports of Practical Oncology &Radiotherapy, Volume 23, Issue 5Author(s): Sara Imboden, Laura Knabben, Michael D. Mueller, Andreas R. Günthert, Kristina LösslAbstractAn 81-year-old patient developed an exulcerous tumor in her left breast 21 years after breast cancer treatment with lumpectomy and adjuvant radiotherapy. At the time of the initial treatment 21 years ago, whole breast irradiation was performed with a prescribed dose of 48 Gy and a maximal dose of 69 Gy. In addition, the patient received a 14.7 Gy boost with multicatheter brachytherapy as...
Permanent breast seed implant (PBSI) is an accelerated partial breast irradiation modality for the treatment of early-stage breast cancer. Stranded 103Pd seeds are permanently implanted in and around the post-lumpectomy seroma according to a pre-treatment CT-based plan. Questions have arisen regarding the potential post-implant migration of seeds given the mobility of breast tissue. Further, seed displacements and coalescence have been observed in the weeks following implant by centres performing the technique.
Breast conserving therapy is frequently used to treat early stage breast cancer but the protracted length of whole breast irradiation has made it an unattractive option for some patients. Accelerated partial breast irradiation (APBI) is used to treat the lumpectomy cavity alone in a shorter amount of time, conventionally in 10 fractions twice daily over 5 days. The SenoRx study opened by Contura, was a multi-site prospective phase II non-randomized dose-escalation trial for APBI using a multi-lumen balloon 3 or 4 fractions over 2 days.