Quality of Life in Irish Patients with Non Muscle Invasive Bladder Cancer

Publication date: 2019Source: European Urology Supplements, Volume 18, Issue 5Author(s): S. O’Meara, S. Considine, S. Anderson, M. Aboelmagd, S. Connolly, D. Galvin, N. Hegarty, K.J. O’Malley
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research

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Authors: Su Q, Luo S, Tan Q, Deng J, Zhou S, Peng M, Tao T, Yang X Abstract Cancer cells are characterized by a high glycolytic rate, which leads to energy regeneration and anabolic metabolism; a consequence of this is the abnormal expression of pyruvate kinase isoenzyme M2 (PKM2). Multiple studies have demonstrated that the expression levels of PKM2 are upregulated in numerous cancer types. Consequently, the mechanism of action of certain anticancer drugs is to downregulate PKM2 expression, indicating the significance of PKM2 in a chemotherapeutic setting. Furthermore, it has previously been highlighted that the d...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In conclusion, the results suggest that the recurrence of GBM is associated with high gene expression levels VEGFA and CXCL8, and the development of the central nervous system. PMID: 31788092 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
lncRNA AWPPH promotes the migration and invasion of glioma cells by activating the TGF-β pathway. Oncol Lett. 2019 Dec;18(6):5923-5929 Authors: Dai B, Xiao Z, Mao B, Zhu G, Huang H, Guan F, Su H, Lin Z, Peng W, Hu Z Abstract The long noncoding RNA (lncRNA) AWPPH, also termed microRNA-4435-2HG, has been associated with the poor prognosis of patients with hepatocellular carcinoma (HCC), and has been demonstrated to promote the progression of HCC and bladder cancer. The present study aimed to investigate the role of lncRNA AWPPH in glioma. The expression levels of AWPPH in tumor tissues obtained from...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Qi Z, Yuan L, Sun N Abstract 2,6-diisopropylphenol (propofol) is a commonly used intravenous anesthetic drug, which has been reported to serve an antitumor role in human cancers. The current study aimed to assess the effects of propofol on the biological behaviors of human bladder cancer cells and to elucidate its potential molecular mechanism. The results of MTT, wound healing and Matrigel invasion assays demonstrated that propofol significantly inhibited the viability, migration and invasion of bladder cancer T24 cells in vitro. Reverse transcription-quantitative PCR and western blotting revealed that pr...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
CONCLUSION: Hyperthermic Mitomycin using the HIVEC® device is a rather safe and well tolerated treatment. Efficiency remains partial as 27.3% of patients experienced recurrence during the first year. These data should be confirmed by prospective multicentric studies. PMID: 31787540 [PubMed - as supplied by publisher]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
BALVERSA is a drug for the treatment of a type of bladder and urinary tract cancer called urothelial carcinoma. BALVERSA may be used in patients with urothelial carcinoma: whose tumors have a certain type of abnormal (FGFR) gene and whose cancer has spread (locally advanced or metastatic urothelial
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
Condition:   Bladder Cancer Interventions:   Drug: Atezolizumab Injection [Tecentriq];   Radiation: External Beam Radiation Therapy (EBRT) Sponsors:   Spanish Oncology Genito-Urinary Group;   Roche Farma, S.A;   Dynamic Science S.L. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Current treatments for bladder cancer need improvement. A new study combines a growth factor with anthrax toxin to create a quick, effective treatment.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
Two common beauty products—permanent hair dyes and chemical straighteners—may be associated with an elevated risk for breast cancer, according to a new study published in the International Journal of Cancer. Hair dyes have been linked to other cancers before, though the research is inconclusive. Bladder and blood cancers have been examined most closely, according to the American Cancer Society, with the most consistent results pointing to a small increase in bladder cancer risk for salon employees. Meanwhile, most studies to date looking specifically at dye and breast cancer have not found a connection. The pic...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Cancer Source Type: news
Patients with bladder cancer (BCa) with clinical lymph node (LN) metastasis have an extremely poor prognosis. VEGF-C has been demonstrated to play vital roles in LN metastasis in BCa. However, approximately 20% of BCa with LN metastasis exhibits low VEGF-C expression, suggesting a VEGF-C–independent mechanism for LN metastasis of BCa. Herein, we demonstrate that BCa cell–secreted exosome-mediated lymphangiogenesis promoted LN metastasis in BCa in a VEGF-C–independent manner. We identified an exosomal long noncoding RNA (lncRNA), termed lymph node metastasis-associated transcript 2 (LNMAT2), that stimulate...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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