Role of CTHRC1 in Diagnosis of Rheumatoid Arthritis

Condition:   Rheumatoid Arthritis Intervention:   Diagnostic Test: CTHRC1 biomarker Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Any of you have any luck successfully managing a patient who argues with you that their lab results are abnormal, demanding tests that aren't indicated? I have done more of a work up than most would have done at this point and I do not think more testing is warranted. Example platelets of 180 they state is "lower end of normal, and is therefore abnormal," "a basophil percentage of 0.3% is low" and wanting rheumatoid arthritis work up with only symptom being dyspepsia. Explaining that... Dealing with difficult patients
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Family Medicine Source Type: forums
Acid sphingomyelinase activity is elevated in serum of rheumatoid arthritis patients, suppressed by anti-TNF-α treatment. Clin Exp Rheumatol. 2019 Oct 08; Authors: Chung HY, Wickel J, Stuhlmüller B, Kinne RW, Claus RA PMID: 31603070 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Publication date: Available online 11 October 2019Source: Life SciencesAuthor(s): Qiqi Xin, Rong Yuan, Weili Shi, Zhengchuan Zhu, Yan Wang, Weihong CongAbstractInflammatory disorders result from abnormal immune response and their incidence has increased recently. Thus, there is an urgent need to discover new treatments for inflammatory disorders. In recent years, the natural products contained in Chinese herbs have attracted much attention worldwide owing to their anti-inflammatory effects. Paeoniflorin (PF) is a bioactive compound purified from the Chinese herb Paeonia lactiflora and reports have recently emerged suggesti...
Source: Life Sciences - Category: Biology Source Type: research
Authors: Toraih EA, Ameen HM, Hussein MH, Youssef Elabd AA, Mohamed AM, Abdel-Gawad AR, Fawzy MS Abstract Alopecia areata (AA) is a non-scarring hair loss of autoimmune etiology. The autoimmune regulator (AIRE) gene is believed to be an important driver in AA pathogenesis. Genetic variants can alter mRNA expression levels which may provoke an autoimmune response. A total of 337 males (97 AA patients and 240 controls) were enrolled in the current case-control study. On screening of the most frequent variants in the gene, rs2075876 (A/G) polymorphism in intron 5 was selected and genotyped using Real-Time PCR (polymer...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
ConclusionFrom these results, it was proved that A. speciosa seeds prevent tissue damage due to oxidative stress with strong antioxidant activity.Graphical abstract
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
The objective was to monitor CV risk factor behavior in the early stages of the disease and to identify predictors of major CV outcomes (MACE). A recent-onset RA cohort was initiated in 2004; data from 185 patients with  ≥ 1 year of follow-up were analyzed. Patients underwent prospective assessments of CV risk factors. Incident MACE were confirmed according to standardized definitions. Appropriated statics was used based on the distribution of the variables. At baseline, patients were primarily middle-aged f emales (87.6%), with active disease (69.7%). Most prevalent CV risk factors were C-reactive-pr...
Source: Rheumatology International - Category: Rheumatology Source Type: research
st S, Kastbom A Abstract OBJECTIVE: To evaluate secretory antibodies to citrullinated proteins (ACPA) in plasma and IgA ACPA in saliva from patients with rheumatoid arthritis (RA) and their unaffected first-degree relatives (FDRs). METHODS: Patients with RA (n=194) and first-degree relatives unaffected by RA (n=191) were recruited for analysis of secretory antibodies to 2nd generation cyclic citrullinated peptides (anti-CCP) in plasma. From a subpopulation (25 RA patients, 21 first-degree relatives and 11 controls), saliva samples were obtained for IgA anti-CCP analysis. The presence of secretory ACPA was com...
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research
Abstract Treatment options for vitiligo are limited and many cases remain refractory to first and second line treatments. Interferon-gamma signaling mediated by Janus kinase (JAK) has been implicated in the pathogenesis of vitiligo.1 Systemic administration of tofacitinib, a potent JAK1/3 inhibitor, has been effective in treating vitiligo in case reports,2 however, it is associated with infections, malignancies, cytopenias, gastrointestinal perforations, and hyperlipidemia in some patients with rheumatoid arthritis. PMID: 31605536 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Sterile inflammation arises without external cause, such as infection or injury, and chronic sterile inflammation is a characteristic of aging. Inflammatory signaling becomes constant and pronounced in tissues, and the immune system is constantly roused to action. Processes, such as regeneration from injury, that depend upon a clear cycle of inflammation that starts, progresses, and resolves are significantly disrupted. It is no exaggeration to say that the downstream consequences of chronic inflammation accelerate the progression of all of the common age-related conditions. It is of great importance in atherosclerosis and...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
ConclusionsThese recommendations aim to facilitate decision-making with the use of combined therapy with DMARD in RA.ResumenObjetivo1) Revisar sistemática y críticamente la evidencia sobre eficacia y seguridad de la terapia combinada con fármacos modificadores de la enfermedad (FAME) sintéticos en la artritis reumatoide (AR); 2) Emitir recomendaciones prácticas sobre su uso.MétodosSe realizó una revisión sistemática de la literatura con una estrategia de búsqueda bibliográfica sensible en Medline, Embase y Cochrane Library. Se seleccionaron ensayo...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
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