Synovial Fluid Biomarkers Pre and Post Hymovis Knee Injection

Condition:   Knee Osteoarthritis Intervention:   Drug: Hymovis Sponsors:   National Jewish Health;   Fidia Pharma USA Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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ConclusionDespite the recovery of patients after ACL reconstruction during long-term follow-up in athletes, return to sport activity similar to pre-injury in female, older peoples, overweight patients and athletes with chondral lesion were lower. However, these conditions do not apply to the meniscus rupture.
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
In this study, AT1-AAs were detected in the sera of patients with peripheral arterial disease (PAD) and the positive rate was 44.44% vs. 17.46% in non-PAD volunteers. In addition, analysis showed that AT1-AAs level was positively correlated with PAD. To reveal the causal relationship between AT1-AAs and vascular aging, an AT1-AAs-positive rat model was established by active immunization. The carotid pulse wave velocity was higher, and the aortic endothelium-dependent vasodilatation was attenuated significantly in the immunized rats. Morphological staining showed thickening of the aortic wall. Histological examination showe...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
SUNDAY, Oct. 20, 2019 -- Osteoarthritis is the most common form of arthritis, affecting about 31 million Americans, and is the leading cause of disability among adults. Known as OA, it causes pain and other symptoms in joints, which can affect the...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
ConclusionThe occurrence of morphologic ACL change after OWHTO is associated with the amount of MTS change.Level of EvidenceIII, Retrospective comparative study.
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
Authors: Ghouri A, Conaghan PG Abstract Osteoarthritis (OA) is a debilitative, painful condition with significant global burden. Pharmacological options have limited analgesic efficacy and their side-effects often restrict their use. Novel pharmacological options are needed to relieve patient symptoms and their consequent disease impact. A variety of pharmacological options have been investigated in treating OA, including existing therapies previously used for treating other arthritides (such as colchicine and hydroxychloroquine) and new therapies targeting pain (including monoclonal antibodies to nerve growth fact...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Swingler TE, Niu L, Smith P, Paddy P, Le L, Barter MJ, Young DA, Clark IM Abstract MicroRNAs are small double-stranded RNAs, which negatively regulate gene expression and have been shown to have key roles in both chondrocyte development and cartilage homeostasis with age. Deletion of all microRNAs in chondrocytes leads to skeletal growth defects in mice, whilst deletion of specific microRNAs, e.g. miR-140, leads to premature articular cartilage degradation and increased susceptibility to posttraumatic osteoarthritis. Studies comparing microRNA expression in normal human articular cartilage compared to oste...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Deveza LA, Nelson AE, Loeser RF Abstract In the most recent years, an extraordinary research effort has emerged to disentangle osteoarthritis heterogeneity, opening new avenues for progressing with therapeutic development and unravelling the pathogenesis of this complex condition. Several phenotypes and endotypes have been proposed albeit none has been sufficiently validated for clinical or research use as yet. This review discusses the latest advances in OA phenotyping including how new modern statistical strategies based on machine learning and big data can help advance this field of research. PMID: ...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Carlesso LC, Neogi T Abstract Knee pain in osteoarthritis is complex and complicated by the fact that osteoarthritis is considered to be a disorder of multiple phenotypes. This complexity challenges our understanding as to why some people remain relatively symptom-free, while others progress to persistent pain. One approach to understanding the mechanisms underlying the transition to persistent pain is by identifying pain susceptibility phenotypes in people with or at risk of knee osteoarthritis. Using variables representative of the multidimensional nature of pain in people who were free of persistent pai...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
The "elusive DMOAD": Aggrecanase inhibition from laboratory to clinic. Clin Exp Rheumatol. 2019 Sep-Oct;37 Suppl 120(5):130-134 Authors: Malfait AM, Tortorella MD Abstract From the time of their discovery in 1999, the aggrecanases, and ADAMTS-5 in particular, have been heavily investigated as targets for disease-modifying osteoarthritis drug (DMOAD) development. Here, we provide a brief narrative review of the discovery efforts to target these enzymes, and how this led to the current ongoing programmes that hold promise for the future. We discuss a comparison of inhibition of collagen breakdo...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Hayashi D, Roemer FW, Guermazi A Abstract Magnetic resonance imaging (MRI) is a well-established imaging technique for structural assessment of knee osteoarthritis (OA) particularly in a research context. Conventional MRI allows evaluation of morphological changes in osteoarthritis, and advanced compositional MRI techniques enable assessment of 'premorphologic' biochemical compositional changes of articular and periarticular tissues. Limitations of conventional radiography are well known, although radiography remains the primary imaging modality applied in osteoarthritis clinical trials to date. Hybrid tec...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
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