Lipid Turnover in Fat Tissue Decreases with Age

Researchers here show that lipid turnover in fat tissue decreases with age, and suggest that this mechanism explains some fraction of the tendency to gain weight with age. Everyone of a certain age recognizes that it takes ever more effort to evade or get rid of excess fat tissue. It remains an open question as to which underlying mechanisms cause this change in lipid turnover, though given progress in rejuvenation research we are at the point of being able to test hypotheses such as chronic inflammation resulting from senescent cells, or mitochondrial dysfunction. We shall see what new data on this topic emerges in the years ahead. Scientists studied the fat cells in 54 men and women over an average period of 13 years. In that time, all subjects, regardless of whether they gained or lost weight, showed decreases in lipid turnover in the fat tissue, that is the rate at which lipid (or fat) in the fat cells is removed and stored. Those who didn't compensate for that by eating less calories gained weight by an average of 20 percent, according to the study. The researchers also examined lipid turnover in 41 women who underwent bariatric surgery and how the lipid turnover rate affected their ability to keep the weight off four to seven years after surgery. The result showed that only those who had a low rate before the surgery managed to increase their lipid turnover and maintain their weight loss. The researchers believe these people may have had more room to inc...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs

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Condition:   Severe Obesity Interventions:   Other: Isokinetic Dynamometer;   Other: Bioimpedance Sponsor:   University of Sao Paulo General Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Gut microbiota has been shown to have an important influence on host health. The microbial composition of the human gut microbiota is modulated by diet and other lifestyle habits and it has been reported that microbial diversity is altered in obese people. Obesity is a worldwide health problem that negatively impacts the quality of life. Currently, the widespread treatment for obesity is bariatric surgery. Interestingly, gut microbiota has been shown to be a relevant factor in effective weight loss after bariatric surgery. Since that the human gut microbiota of normal subjects differs between geographic regions, it is poss...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
ConclusionResults of this study indicate that despite largely positive attitudes toward the use of bariatric surgery in a patient population with obesity, primary care physicians report significant barriers to confidently referring their own patients. Further, bariatric surgery is overlooked in a large group of patients with BMIs between 35 and 40 kg/m2. Educational strategies to address these barriers should target rates of specific surgical complications and weight loss outcomes.
Source: Obesity Surgery - Category: Surgery Source Type: research
Conditions:   Diastolic Dysfunction;   Morbid Obesity Intervention:   Sponsor:   Mahidol University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractIntroductionBariatric surgery is increasingly performed. Since there are numerous surgical techniques, the effects of these on the esophageal function are still poorly understood. We aimed at assessing the effect of different techniques on esophagogastric junction (EGJ), esophageal peristalsis and reflux exposure using high-resolution manometry (HRM), and impedance-pH monitoring (MII-pH).MethodsAll obese patients underwent symptomatic questionnaires, endoscopy, HRM, and MII-pH before and 1  year after surgery. Esophageal function and EGJ were classified according to Chicago Classification V. 3.0. Intragastric ...
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
The evidence is clear. Bariatric surgery provides wide-ranging benefits to adolescents with obesity and type 2 diabetes, says Dr Louise Baur.Medscape Diabetes &Endocrinology
Source: Medscape Diabetes Headlines - Category: Endocrinology Tags: Diabetes & Endocrinology Commentary Source Type: news
Study Objectives:Our objectives were to determine in an obese population (body mass index> 35 kg/m2) the number of patients, after gastric bypass (GBP), who no longer met French Ministry of Health criteria for utilizing positive airway pressure (PAP), and the predictive factors of obstructive sleep apnea (OSA) improvement.Methods:Between June 2012 and August 2014 we diagnosed OSA in 129 incident patients requiring PAP therapy before GBP. A postoperative sleep recording was undertaken for 44 of these patients after a weight loss of at least 10%.Results:Most of the patients showed severe OSA with a mean [standard deviatio...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
This article takes the largest US study to date on MBS in adolescents, the TEEN-Labs cohort, and examines BCS use, attitudes and outcomes.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research
Iron deficiency is extremely common after bariatric surgery. HEPCIDIN, encoded by Hamp, is a hormone that negatively regulates iron homeostasis.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Original articles Source Type: research
Obesity has a major impact on the health of women at reproductive age and during pregnancy [1, 2]. Obesity has several deleterious effects on female reproductive function, which includes obesity associated hypothalamic-gonadal dysfunction, fertility impairment and increased rate of miscarriages [3]. Women with obesity also incur in higher risks of pregnancy related mortality and morbidity, since the prevalence of gestational diabetes, fetal growth restriction, prematurity, stillbirth, traumatic delivery and some congenital malformations is increased [2].
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research
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