Feasibility and Safety of CT-Guided High-Dose-Rate Brachytherapy Combined with Transarterial Chemoembolization Using Irinotecan-Loaded Microspheres for the Treatment of Large, Unresectable Colorectal Liver Metastases

Publication date: Available online 16 September 2019Source: Journal of Vascular and Interventional RadiologyAuthor(s): Federico Collettini, Martin Jonczyk, Aymen Meddeb, Gero Wieners, Dominik Geisel, Dirk Schnapauff, Bernhard GebauerAbstractPurposeTo evaluate feasibility and safety of combined irinotecan chemoembolization and CT-guided high-dose-rate brachytherapy (HDRBT) in patients with unresectable colorectal liver metastases> 3 cm in diameter.Materials and MethodsThis prospective study included 23 patients (age, 70 y ± 11.3; 16 men) with 47 liver metastases (size, 62 mm ± 18.7). Catheter-related adverse events were reported per Society of Interventional Radiology classification, and treatment toxicities were reported per Common Terminology Criteria for Adverse Events. Liver-related blood values were analyzed by Wilcoxon test, with P
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research

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Publication date: November–December 2019Source: Reports of Practical Oncology &Radiotherapy, Volume 24, Issue 6Author(s): Ngangom Robert, R.P. Chauhan, Arun Oinam, Bhavana RaiAbstractAimThe aim of this study was to formulate isodose volume relations encompassed by isodose surfaces in Co-60 and Ir-192 HDR intracavitary brachytherapy (ICBT) of cervix carcinoma using the Total Reference Air Kerma (TRAK).BackgroundThe TRAK and isodose volumes are radioactive source related. The formulated relations can easily estimate the irradiated isodose volume if the TRAK and dose are known. The C0-60 can also be used for brachyt...
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
The aim of this review was to examine efficacy of palliative interventional radiotherapy (IRT) in esophageal cancer compared with other treatment in terms of dysphagia-free survival (DyFS) and safety.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Tags: Review Article Source Type: research
This article reviews the development and summarizes the state-of-the-art in absorbed dose calorimetry for all the common clinical beam modalities covered in reference dosimetry codes of practice, as well as for small and nonstandard fields, and brachytherapy. It focuses primarily on work performed in the last ten years by national laboratories and research institutions and is not restricted to primary standard instruments. The most recent absorbed dose calorimetry review article was published over twenty years ago by Ross and Klassen (1996), and even then, its scope was limited to water calorimeters. Since the application ...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
CONCLUSIONS: Penile cancer needs demanding surgery to be cured, surrounded by chemotherapy in node positive patients. Lymph nodes involvement is a major prognostic factor. Thus, inguinal node assessment cannot be neglected. PMID: 31610869 [PubMed - in process]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
High dose-rate (HDR) brachytherapy for recurrent prostate cancer post-radiotherapy is an accepted salvage method. This prospective non-controlled clinical study investigates HDR-like stereotactic body radiotherapy (SBRT) as a less invasive alternative and evaluates efficacy and toxicity in patients with biopsy proven local recurrence. This method appears clinically feasible, with favorable PSA response, disease control to 5 years in the majority of patients, and acceptably low GU and GI toxicity.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
Radical cystectomy (RC) is still considered standard of treatment for patients with non-metastatic muscle-invasive bladder cancer (MIBC) and high-risk non-muscle-invasive bladder cancer (NMIBC) refractory to intravesical therapy in most countries [1]. However, RC has significant morbidity and mortality [2].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
To compare a standard radio-oncological and a surgical biochemical failure definition after combined-modality radiation therapy (CRT) in men with intermediate- and high-risk prostate cancer.
Source: Brachytherapy - Category: Cancer & Oncology Authors: Source Type: research
Condition:   Cervical Cancer Intervention:   Sponsor:   Peking University Third Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, the addition of triapine to cisplatin-radiotherapy improved the rate of metabolic complete response in patients with advanced-stage uterine cervix or vaginal cancers without significant toxicity. A phase III trial adequately powered to evaluate progression-free and overall survival is underway (NCT02466971).
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
The current MRI-CT fusion-based workflow for post-implant dosimetry of Low-Dose-Rate (LDR) prostate brachytherapy takes advantage of the superior soft tissue contrast of MRI but still relies on CT for seed visualization and detection. Recently an MR-only workflow has been proposed that employs standard MR sequences and visualizes conventional implanted seed with positive contrast solely through MR post-processing. In this work, the novel MR-only based workflow is compared to the clinical CT-MRI fusion approach.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
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