Somatic mutations of candidate tumor suppressor genes folliculin-interacting proteins FNIP1 and FNIP2 in gastric and colon cancers

Publication date: Available online 16 September 2019Source: Pathology - Research and PracticeAuthor(s): Ha Yoon Mo, Hyun Ji Son, Eun Ji Choi, Nam Jin Yoo, Chang Hyeok An, Sug Hyung Lee
Source: Pathology Research and Practice - Category: Pathology Source Type: research

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ConclusionOur study demonstrated a significant correlation between Nectin-4 expression and tumor grade as well as stages (p 
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Conclusions: Our data support that COX-2 is involved in the early stages of colorectal cancer development, initially affecting the tumor’s stromal microenvironment, and, subsequently, the epithelial cells. They also highlight an inverse correlation between COX-2 expression and telomerase activity in CRC, as well as differentially methylated patterns within the promoter regions of COX-2 and TERT.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
AbstractThe reaction of cyclohexan-1,3-dione with either of malononitrile or ethyl cyanoacetate gave the 4-amino-6,7-dihydro-5H-chromen-5-one derivatives3a and3b, respectively. The reaction of the latter compounds with cyanoacetylhydrazine gave the hydrazide –hydrazone derivatives5a and5b, respectively. Compounds5a,b were used as the key starting materials for the synthesis of thiophen, coumarin, and pyridine derivatives. The newly synthesized compounds were evaluated against three human cancer cell lines, including HCT116 (colon carcinoma cell), MGC803 (gastric carcinoma cell), and Huh7 (hepatoma carcinoma cell). Th...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
Publication date: December 2019Source: Biomedicine &Pharmacotherapy, Volume 120Author(s): Wenjie Huang, Jia Cao, Xuxia PengAbstractLINC01234 plays a pivot role in the tumorigenesis of gastric cancer, colon cancer and lung cancer. However, how LINC01234 participates in oral squamous cell carcinoma (OSCC) progression remains unknown. In our research, we showed that LINC01234 was dramatically upregulated in OSCC tissues. And interestingly, high LINC01234 expression predicted a low overall survival rate in OSCC patients. Knockdown of OSCC inhibited the proliferation of cancer cells and led to more cells restricted in G0 ph...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
ConclusionThe most common cancers were those associated with 'westernisation' of lifestyle. Our figures contrast with other Sub-Saharan Africa countries where infection related cancers are most predominant. The MNCR has also improved its data quality over time.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Abstract LINC01234 plays a pivot role in the tumorigenesis of gastric cancer, colon cancer and lung cancer. However, how LINC01234 participates in oral squamous cell carcinoma (OSCC) progression remains unknown. In our research, we showed that LINC01234 was dramatically upregulated in OSCC tissues. And interestingly, high LINC01234 expression predicted a low overall survival rate in OSCC patients. Knockdown of OSCC inhibited the proliferation of cancer cells and led to more cells restricted in G0 phase. Moreover, LINC01234 silencing decreased the migration and invasion of OSCC cells. Additionally, downregulation o...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Neuroendocrine tumors (NETs) arise from the cells present throughout the diffuse endocrine system. These neoplasms were previously regarded as rare, but in fact are increasing in incidence (3.65/100 000 individuals/y). Enhancer of zeste homolog 2 (EZH2) plays a crucial role in cell cycle regulation, and it was reported to be overexpressed in several tumors. The aim of the study was to investigate EZH2 expression, also related with proliferation rate, and p53 expression in NETs of the intestine encompassing a group of tumors primary to the stomach, appendix, small intestine, and colon. The specimens from 33 patients with ne...
Source: Applied Immunohistochemistry and Molecular Morphology - Category: Chemistry Tags: Research Articles Source Type: research
AbstractBackgroundThe AVANT study did not demonstrate disease-free survival (DFS) benefit of the addition of bevacizumab to oxaliplatin-based chemotherapy in stage III resected CC and suggested a potential detrimental effect on overall survival (OS) (A. de Gramont et al. Lancet Oncol. 2012). Here, we present the results of the AVANT study for stage II CC patients.MethodsThe primary endpoint of AVANT was DFS for stage III disease. As an exploratory measure, AVANT also included high-risk stage II CC defined by T4, bowel obstruction or perforation, blood and/or lymphatic vascular invasion and/or perineural invasion, age
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsFrom these data, we infer that MACC1 regulates PDL1 expression and tumor immunity through the c ‐Met/AKT/mTOR pathway in GC cells and suggest that MACC1 may be a therapeutic target for GC immunotherapy.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Ethicon, a part of J&J, just unveiled the ECHELON CIRCULAR, which the company touts as the first powered circular stapler specifically designed for colorectal, gastric, and thoracic procedures. The device features so-called “Gripping Sur...
Source: Medgadget - Category: Medical Devices Authors: Tags: GI Surgery Thoracic Surgery Source Type: blogs
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