Enhancing the efficacy of colonoscopy in Lynch syndrome: the search for the holy grail continues

Haanstra and coauthors1 share the results from their randomized controlled trial assessing the impact of proximal colon chromoendoscopy for the detection of neoplasia at baseline and follow-up colonoscopy in patients with Lynch syndrome (LS) performed across 6 centers in the Netherlands. In the trial, indigo carmine chromoendoscopy application in the proximal colon was compared with standard white-light endoscopy (WLE) in 246 mismatch repair gene mutation carriers. Although chromoendoscopy led to a significantly increased median withdrawal time (19 vs 12 minutes), no improvement in the number of patients detected with neoplasia was observed (30% vs 27%).
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research