Il-6 involvement in pain, fatigue and mood disorders in rheumatoid arthritis and the effects of il-6 inhibitor sarilumab

Publication date: Available online 16 September 2019Source: Pharmacological ResearchAuthor(s): Fabiola Atzeni, Valeria Nucera, Ignazio Francesco Masala, Piercarlo Sarzi-Puttini, Gianluca BonittaABSTRACTInterleukin 6 (IL-6) is a pleiotropic cytokine that plays a role in the neuroendocrine system, insulin resistance, lipid metabolism, vascular disease, mitochondrial activities, neuropsychological behaviour, and also mediates communications between the immune and central nervous system (CNS). Treatment with anti-IL-6 or anti-IL-6R agents seems to alleviate allodynia and hyperalgesia, so it may be a valid option when treating the many conditions involving pathological pain as rheumatoid arthritis.Graphical abstractThis review is focused on the role Interleukin 6 (IL-6), a cytokine that plays a role in the neuroendocrine system, insulin resistance, lipid metabolism, vascular disease, mitochondrial activities, neuropsychological behaviour, and mediates communications between the immune and central nervous system (CNS) in rheumatoid arthritis. Furthermore, we underlined the effect of anti-IL6 inhibitor sarilumab on pain, mood disorders and fatigue based on the results of three phases III clinical trials.
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research

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Source: Frontiers in Physiology - Category: Physiology Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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