Improvement of Spinal Muscular Atrophy via Correction of the SMN2 Splicing Defect by Brucea javanica (L.) Merr. Extract and Bruceine D

ConclusionOur work revealed that B. javanica and Bruceine D correct the SMN2 splicing defect and improve the symptoms of SMA in mice. These resources will provide another possibility for development of a plant-derived SMA drug candidate.
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research