A neonatal pustule:Langerhans cell histiocytosis
We present a case of single lesion self-limited LCH in a full-term male infant with interesting morphology. Physical examination revealed a painless, 6 millimeter, well-demarcated, papule encircled by erythema with central hemorrhage. An infectious workup was negative and a punch biopsy was obtained, which showed a dermal infiltrate of histiocytes consistent with a diagnosis of LCH. The lesion healed without intervention within three weeks. Our case highlights the need for dermatologists to consider LCH in the differential diagnosis for lesions...
Condition: Langerhans Cell Histiocytosis Intervention: Drug: Cytarabine Sponsor: Peking Union Medical College Hospital Recruiting
Condition: Langerhans Cell Histiocytosis Intervention: Drug: thalidomide combined with dexamethasone and cyclophosphamide Sponsor: Peking Union Medical College Hospital Recruiting
Shalendra Singh, Shreyas Kate, Rashmi Datta, Virender SuhagIndian Journal of Anaesthesia 2019 63(10):866-868
ConclusionsSP is a common manifestation of PLCH, can be seen in approximately one-fourth of the patients, and has a high recurrence risk. Surgical pleurodesis leads to a substantial reduction in the SP recurrence risk. The risk of an air travel-related SP in patients with PLCH is about 2–3 per thousand flights.Trial registry clinicaltrials.govNCT03052101.
Abstract This is a case of a pediatric male who presented with a postauricular mass and pain. Computed tomography and magnetic resonance imaging suggested a diagnosis of Langerhans cell histiocytosis. Characteristic imaging findings and initial workup for Langerhans cell histiocytosis are described. PMID: 31558057 [PubMed - as supplied by publisher]
Condition: Histiocytosis, Langerhans-Cell Interventions: Other: Biospecimen Collection; Other: Laboratory Biomarker Analysis; Other: Questionnaire Administration Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Not yet recruiting