Long noncoding RNA TTN-AS1 enhances the malignant characteristics of osteosarcoma by acting as a competing endogenous RNA on microRNA-376a thereby upregulating dickkopf-1.

In conclusion, TTN-AS1 functions as a competing endogenous RNA targeting miR-376a and increases the malignancy of OS cells in vitro and in vivo by upregulating DKK1. PMID: 31525734 [PubMed - as supplied by publisher]
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research

Related Links:

Publication date: January 2020Source: Materials Science and Engineering: C, Volume 106Author(s): Elia Marin, Tetsuya Adachi, Matteo Zanocco, Francesco Boschetto, Alfredo Rondinella, Wenliang Zhu, Shota Somekawa, Ryutaro Ashida, Ryan M. Bock, Bryan J. McEntire, B. Sonny Bal, Osam Mazda, Giuseppe PezzottiAbstractUsing a simple and innovative sandblasting process, disks of monolithic biomedical silicon nitride (β-Si3N4) were texturized with a matrix of regular, discrete square trenches with a total depth in the range of hundreds of microns. The process consisted of sandblasting Si3N4 substrates through a stainless-steel ...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: January 2020Source: Materials Science and Engineering: C, Volume 106Author(s): O. Mitxelena-Iribarren, J. Campisi, I. Martínez de Apellániz, S. Lizarbe-Sancha, S. Arana, V. Zhukova, M. Mujika, A. ZhukovAbstractLimitations in effectiveness and the invasive nature of current cancer treatment options emphasize the need for further clinical advancements. Among other approaches, targeted hyperthermia is as a new strategy aimed at targeting cancerous cells to improve the efficacy of radiotherapy or cytotoxic drugs. However, the testing of magnetic vehicles has mainly focused on the use of nanopart...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In conclusion, we established and characterized a novel ESOS cell line, NCC-ESOS1-C1. This cell line will be a useful resource for basic research and preclinical studies.
Source: Human Cell - Category: Cytology Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Authors: Xu W, Lou Y, Chen W, Kang Y Abstract Effective cancer therapy usually requires the assistance of well-designed drug carriers. In order to increase the drug accumulation to tumor tissue as well as to reduce the side effects of drug carriers, the hybrid drug delivery system (DDS) was developed by integrating folic acid (FA) and a metal-organic framework (MOF). The anticancer drug doxorubicin (DOX) was preloaded into the MOF nanoparticles during the synthesis process of the MOF nanoparticles. After surface modification with FA, the resulting FA/MOF/DOX nanoparticles were capable of serving as a biocompatible ...
Source: Biomedizinische Technik/Biomedical Engineering - Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research
Publication date: Available online 12 October 2019Source: Pathology - Research and PracticeAuthor(s): Kun Chen, Guobiao PanAbstractMicroRNA-106a-5p (miR-106a-5p) functions as a tumor suppressor in osteosarcoma cells. Here, we aimed to identify novel target genes of miR-106a-5p in osteosarcoma, as well as to investigate their prognostic value and the biological functions. At first, the mammalian runt-related factor 1 (RUNX1) was identified as one of the target genes of miR-106a-5p in osteosarcoma cells by luciferase reporter gene assay, real-time quantitative RT-PCR and Western blot analysis. Then, the expression levels of ...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
This study aimed to explore the effect of a circular RNA (circRNA), circ_0102049, on OS and reveal its potential molecular mechanism. In this work, the expression of circ_0102049 was detected by quantitative real time polymerase chain reaction (qRT-RCR) in both OS specimens and cell lines. The relationship between circ_0102049 level and patientsÔ┐┐ overall survival was evaluated by Kaplan-Meier curves and Cox regression analysis. Cell proliferation, apoptosis, migration and invasion of U2OS and MG63 cells were measured by cell counting kit-8 (CCK-8), flow cytometry, wound healing and transwell experiments, respectively. In...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Aberrant expression of cyclin-dependent protein kinases (CDK) is a hallmark of cancer. CDK11 plays a crucial role in cancer cell growth and proliferation. However, the molecular mechanisms of CDK11 and CDK11 t...
Source: Cell Communication and Signaling - Category: Molecular Biology Authors: Tags: Research Source Type: research
Austin Degnan, of Illinois, was diagnosed with osteosarcoma earlier this year, after complaining of a severe pain in his left leg. He underwent a surgical procedure called a rotationplasty.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
More News: Biomedical Science | Bone Cancers | Cancer & Oncology | Osteosarcoma | Study