Viruses, Vol. 11, Pages 868: Medical Outcomes in Women Who Became Pregnant after Vaccination with a Virus-Like Particle Experimental Vaccine against Influenza A (H1N1) 2009 Virus Tested during 2009 Pandemic Outbreak

Viruses, Vol. 11, Pages 868: Medical Outcomes in Women Who Became Pregnant after Vaccination with a Virus-Like Particle Experimental Vaccine against Influenza A (H1N1) 2009 Virus Tested during 2009 Pandemic Outbreak Viruses doi: 10.3390/v11090868 Authors: Arturo Cérbulo-Vázquez Lourdes Arriaga-Pizano Gabriela Cruz-Cureño Ilka Boscó-Gárate Eduardo Ferat-Osorio Rodolfo Pastelin-Palacios Ricardo Figueroa-Damian Denisse Castro-Eguiluz Javier Mancilla-Ramirez Armando Isibasi Constantino López-Macías The clinical effects and immunological response to the influenza vaccine in women who later become pregnant remain to be thoroughly studied. Here, we report the medical outcomes of 40 women volunteers who became pregnant after vaccination with an experimental virus-like particle (VLP) vaccine against pandemic influenza A(H1N1)2009 (influenza A(H1N1)pdm09) and their infants. When included in the VLP vaccine trial, none of the women were pregnant and were randomly assigned to one of the following groups: (1) placebo, (2) 15 μg dose of VLP vaccine, or (3) 45 μg dose of VLP vaccine. These 40 women reported becoming pregnant during the follow-up phase after receiving the placebo or VLP vaccine. Women were monitored throughout pregnancy and their infants were monitored until one year after birth. Antibody titers against VLP were measured in the mothers and infants at delivery and at six months and one year after birth. The incidence of...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research