Drs. Mavragani and Moutsopoulos reply.

Drs. Mavragani and Moutsopoulos reply. J Rheumatol. 2019 Sep 15;: Authors: Mavragani CP, Moutsopoulos HM Abstract We were delighted to read the letter by Killian, et al, which challenges the use of the terms primary and secondary human Sjögren syndrome (SS) even in experimental animal models of SS1 These terms were coined almost 40 years ago on the basis of a study that revealed clinical, immunologic, and genetic differences among patients expressing sicca manifestations alone and patients with rheumatoid arthritis (RA) and SS. PMID: 31523045 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research

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Two JAK inhibitors, one recently approved by the FDA, have shown improvements in patients with active RA for whom other therapies have proved ineffective...
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AbstractObjectivesTo study the involvement of regulatory T cells (Tregs) expressing tumor necrosis factor ‐αreceptor 2 (TNFR2) incontrol of experimental inflammation and response to treatment in rheumatoid arthritis (RA) and spondyloarthritis (SpA).MethodsThe role of TNFR2 inTregswas exploredusing amultilevel translational approach.Tregstability was evaluatedby analyzing methylation status of thefoxp3locus by bisulfite sequencing. Two models of inflammation (imiquimod ‐induced skin inflammationand delayed type hypersensitivity arthritis, DTHA) were induced inTNFR2‐deficient (TNFR2‐/‐) micewith or without tr...
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The Pharmacogenomics Journal, Published online: 14 October 2019; doi:10.1038/s41397-019-0097-xFolyl polyglutamate synthethase (FPGS) gene polymorphisms may influence methotrexate adverse events in South Indian Tamil Rheumatoid Arthritis patients
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In conclusion, a polypharmacology approach of combining established, prolongevity drug inhibitors of specific nodes may be the most effective way to target the nutrient-sensing network to improve late-life health. Deletion of p38α in Neurons Slows Neural Stem Cell Decline and Loss of Cognitive Function in Mice https://www.fightaging.org/archives/2019/10/deletion-of-p38%ce%b1-in-neurons-slows-neural-stem-cell-decline-and-loss-of-cognitive-function-in-mice/ Researchers here provide evidence for p38α to be involved in the regulation of diminished neural stem cell activity with age. It is thought...
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Any of you have any luck successfully managing a patient who argues with you that their lab results are abnormal, demanding tests that aren't indicated? I have done more of a work up than most would have done at this point and I do not think more testing is warranted. Example platelets of 180 they state is "lower end of normal, and is therefore abnormal," "a basophil percentage of 0.3% is low" and wanting rheumatoid arthritis work up with only symptom being dyspepsia. Explaining that... Dealing with difficult patients
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Acid sphingomyelinase activity is elevated in serum of rheumatoid arthritis patients, suppressed by anti-TNF-α treatment. Clin Exp Rheumatol. 2019 Oct 08; Authors: Chung HY, Wickel J, Stuhlmüller B, Kinne RW, Claus RA PMID: 31603070 [PubMed - as supplied by publisher]
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