Eccentric and Concentric Resistance Exercise Comparison for Knee Osteoarthritis
This study aimed to compare the efficacy of eccentrically focused resistance exercise (ECC RT) to concentrically focused resistance exercise (CNC RT) on knee osteoarthritis (OA) symptoms and strength. Methods Ninety participants consented. Participants were randomized to CNC RT, ECC RT, or a wait-list, no-exercise control group. Four months of supervised exercise training was completed using traditional weight machines (CNC RT) or modified-matched machines that overloaded the eccentric action (ECC RT). Main outcomes included one-repetition maximal strength (knee extension, leg flexion, and leg press), weekly rate of strength gain, Western Ontario and McMaster University Osteoarthritis Index (WOMAC) total score and subscores. Results Fifty-four participants (60–85 yr, 61% women) completed the study. Both CNC RT and ECC RT groups showed 16%–28% improvement relative to the wait-list, no-exercise control group (P = 0.003–0.005) for all leg strength measures. The rate of weekly strength gain was greater for CNC RT than for ECC RT for leg press and knee flexion (by 2.9%–4.8%; both, P
Condition: Knee Osteoarthritis Interventions: Biological: Low Dose of Mesenchymal stem cell; Biological: High Dose of Mesenchymal stem cell; Drug: Sodium Hyaluronate Sponsor: CAR-T (Shanghai) Biotechnology Co., Ltd. Recruiting
Condition: Osteoarthritis, Knee Interventions: Drug: UBX0101; Other: Placebo Sponsor: Unity Biotechnology, Inc. Recruiting
This pilot study examined whether chair yoga and chair-based exercise are effective in managing biopsychosocial outcomes for older adults with lower extremity osteoarthritis. Both interventions improved physical function and mobility over time, although no significant differences between the 2 interventions were identified.
This article identifies 11 running-related questions that patients may ask and provides information to help answer those questions. This review discusses data on the health benefits of running, common running injuries, the relationship between running and osteoarthritis, recommendations regarding running after orthopaedic surgery, running shoes, and other questions that may arise when treating the running athlete. PMID: 31613816 [PubMed - as supplied by publisher]
Glucocorticoids (GCs) are known to have a strong impact on the immune system, metabolism, and bone homeostasis. While these functions have been long investigated separately in immunology, metabolism, or bone biology, the understanding of how GCs regulate the cellular cross-talk between innate immune cells, mesenchymal cells, and other stromal cells has been garnering attention rather recently. Here we review the recent findings of GC action in osteoporosis, inflammatory bone diseases (rheumatoid and osteoarthritis), and bone regeneration during fracture healing. We focus on studies of pre-clinical animal models that enable...
ConclusionThe tap test has the advantages of high sensitivity, simple operation, and less radiation exposure, suggesting that it is of high diagnostic value for assessing the integrity of the acute deltoid ligament.
AbstractObjectivesOur study objective was to explore whether abnormalities in the subtypes of T cells and B cells were present in peripheral blood of patients with osteoarthritis (OA) and healthy controls (HCs).MethodDemographic and clinical variables and blood were collected. OA severity was measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire. Flow cytometry was used to establish the frequencies of lineage subsets. Monoclonal antibodies against 21 surface markers were used to distinguish and evaluate T cells ’ and B cells’ subpopulation. The proportion of eac...
BOSTON (CBS) – Many Americans with aching joints are offered steroid injections to help ease their pain, but local researchers say those shots are causing more harm. Steroid injections, often combined with a local anesthetic, are commonly used to treat hip and knee pain associated with osteoarthritis. Researchers at the Boston University School of Medicine reviewed data on hundreds of joint injections performed in 2018 and found that, in some patients, those shots were associated with acceleration of the arthritis, fractures, and bone loss. The researchers say that, while more study is needed, radiologists and ...
Condition: Knee Osteoarthritis Intervention: Device: CyMedica e-vive NMES Sponsor: CyMedica Orthopedics, Inc Recruiting
ConclusionLWAT is a reliable procedure that provides sustained protection against patello-femoral dislocation and good functional scores when used to treat patello-femoral instability due to trochlear dysplasia. Our results do not support claims that LWAT may be associated with high rates of severe osteoarthritis even after more than 20 years.Level of evidenceIV, retrospective observational study with no control group.