Eccentric and Concentric Resistance Exercise Comparison for Knee Osteoarthritis

This study aimed to compare the efficacy of eccentrically focused resistance exercise (ECC RT) to concentrically focused resistance exercise (CNC RT) on knee osteoarthritis (OA) symptoms and strength. Methods Ninety participants consented. Participants were randomized to CNC RT, ECC RT, or a wait-list, no-exercise control group. Four months of supervised exercise training was completed using traditional weight machines (CNC RT) or modified-matched machines that overloaded the eccentric action (ECC RT). Main outcomes included one-repetition maximal strength (knee extension, leg flexion, and leg press), weekly rate of strength gain, Western Ontario and McMaster University Osteoarthritis Index (WOMAC) total score and subscores. Results Fifty-four participants (60–85 yr, 61% women) completed the study. Both CNC RT and ECC RT groups showed 16%–28% improvement relative to the wait-list, no-exercise control group (P = 0.003–0.005) for all leg strength measures. The rate of weekly strength gain was greater for CNC RT than for ECC RT for leg press and knee flexion (by 2.9%–4.8%; both, P
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research

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Condition:   Knee Osteoarthritis Interventions:   Biological: Low Dose of Mesenchymal stem cell;   Biological: High Dose of Mesenchymal stem cell;   Drug: Sodium Hyaluronate Sponsor:   CAR-T (Shanghai) Biotechnology Co., Ltd. Recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Osteoarthritis, Knee Interventions:   Drug: UBX0101;   Other: Placebo Sponsor:   Unity Biotechnology, Inc. Recruiting
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Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Syndicated CBSN Boston Arthritis Boston University School Of Medicine Source Type: news
Condition:   Knee Osteoarthritis Intervention:   Device: CyMedica e-vive NMES Sponsor:   CyMedica Orthopedics, Inc Recruiting
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