Association between Common Genetic Variants in ESR1 and Stroke Risk: A Systematic Review and Meta-Analysis

Objectives: The associations between estrogen receptor alpha (ESR1) polymorphisms and stroke risk have been investigated in various studies, but remain controversial. The aim of this meta-analysis was to determine the relationships between ESR1 rs2234693 and rs9340799 polymorphisms and the risk of stroke. Methods: Electronic databases of PubMed, Embase, Cochrane Library, CNKI, VIP database, and WanFang database were searched for eligible studies up to March 2019. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the strength of associations under different genetic models.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research

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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
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Authors: Leal T, Costa D, Gonçalves R Abstract A 74 year-old male patient was admitted to the emergency department due to diarrhea of a one-month duration. The patient had 5 to 7 bowel movements/day of liquid stool, without blood or mucus. He had also undergone a percutaneous endoscopic gastrostomy (PEG) tube placement 10 weeks previously due to post-stroke dysphagia, with endoscopic confirmation of its correct positioning. A course of antibiotics had already been prescribed and there was no improvement of the symptoms. PMID: 31729231 [PubMed - as supplied by publisher]
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Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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