108 A Prospective Audit and Review of Proton Pump Inhibitors (PPIs) in Older Adults in a Reablement Unit
ConclusionMost patients on a PPI did not have a clear indication.The majority of inappropriate PPIs were deemed suitable for review and were subsequently dose reduced or discontinued.Some patients were unsuitable for PPI review due to multiple risk factors or ongoing symptoms of reflux.The continued need for PPIs should be assessed regularly and a risk-benefit analysis should be carried out.
CONCLUSIONS: In patients with reflux-related symptoms, with or without esophagitis, the water load test is frequently abnormal, suggesting an altered gastric function. Nissen fundoplication is associated with a relatively higher incidence of bloating, epigastric pain and fullness. These preliminary data could explain the incomplete resolution of symptoms after surgery in some patients, and suggest the use of additional studies to explore the gastric function in pre-surgical evaluation. PMID: 31760736 [PubMed - as supplied by publisher]
Conclusions: We believe this would lead to improved provider and patient understanding of a medications adverse reactions and ultimately to improved patient adherence and outcomes.Table 1.Adverse Effects Grid for Riociguat (Adempas®)MildModerateSevereLikely orexpected> 10%Headache (27%)Dyspepsia (13% to 19%)Nausea (14%)Diarrhea (12%)dizziness (20%)Less likelyor possible1-10%Anemia (7%)gastritis (2% to 6%) constipation (5%), gastroesophageal reflux disease (5%)Vomiting (10%)Hypotension (3% to 10%)Rare
[PREVALENCE OF FUNCTIONAL DYSPEPSIA SYMPTOMS IN PATIENTS WITH ASTHMA]. Arerugi. 2019;68(9):1132-1140 Authors: Tomyo F, Sugimoto N, Toyota H, Ito A, Ujino M, Sakasegawa H, Kobayashi K, Koizumi Y, Miyoshi S, Kuramochi M, Yamaguchi M, Yamamoto T, Nagase H Abstract BACKGROUND: Gastroesophageal reflux disease (GERD) is a common comorbidity among patients with asthma. In addition, functional dyspepsia (FD) is characterized by upper abdominal symptoms without organic disease manifestations. However, the prevalence of FD among patients with asthma remains uninvestigated; therefore, herein, we investigated the...
ConclusionThe questioning skill of the community pharmacists in this setting was poor. Few community pharmacists diagnosed the pseudo-patients’ minor ailment correctly. Also, recommendations were mostly inappropriate compared with the standard treatment guideline.
Conclusion: Gabapentin as an adjunctive drug could be more effective in reducing the severity of GI symptoms in patients with dyspepsia, especially neurological symptoms (such as pain, reflux, and indigestion). PMID: 31516891 [PubMed]
Gastrointestinal (GI) motility disorders are major contributing factors to functional GI diseases that account for>40% of patients seen in gastroenterology clinics and affect>20% of the general population. The autonomic and enteric nervous systems and the muscles within the luminal GI tract have key roles in motility. In health, this complex integrated system works seamlessly to transport liquid, solid, and gas through the GI tract. However, major and minor motility disorders occur when these systems fail. Common functional GI motility disorders include dysphagia, gastroesophageal reflux disease, functional dyspepsia...
Authors: Mohammadifard M, Saremi Z, Rastgoo M, Akbari E Abstract There is evidence that infection by H. pylori can have a critical proportion in the development of hepatocyte injury and both noncancerous and malignant liver conditions including non-alcoholic fatty liver disease (NAFLD). This is attributed to several mechanisms, the most important one being the toxic products of the bacterium H. pylori and oxidative injury for hepatocytes which promotes hepatic injury. The present research was aimed at determining the association between H. pylori infection and the prevalence of NAFLD in Birjand, Iran. Two groups we...
Conclusions: Successful treatment of GER-associated cough may be associated with the attenuation of neurogenic and neutrophilic inflammation. PMID: 31303089 [PubMed - as supplied by publisher]
Authors: Kountouras J, Gavalas E, Doulberis M, Polyzos SA, Papaefthimiou A, Touloumtsi M, Vardaka E, Kountouras K, Papanikolopoulou K, Katsinelos P PMID: 31177649 [PubMed - as supplied by publisher]
A 78-year-old female with chronic gastroesophageal reflux disease presented to the primary care office for evaluation of dyspepsia and dysphagia. Upper endoscopy revealed a partially obstructing submucosal tumor 15cm from the incisors. Endoscopic ultrasound (EUS) examined a 2cm heterogenous and multicystic mass in the submucosa. The patient was referred for endoscopic resection.