EP News: Clinical
Schaff et al (J Am Coll Cardiol 2019;74:645, PMID 31370956) evaluated the impact of conduction abnormalities on mortality in patients with obstructive hypertrophic cardiomyopathy after myectomy. The morality of 2482 patients with septal myectomy were analyzed. The mean age at operation was 54.2 ± 14.6 year s, and 1370 patients (55.2%) were men. Preoperatively, 2159 patients (87.0%) had normal conduction. Postoperatively, 38.8% developed left bundle branch block (LBBB), 1.1% developed right bundle branch block (RBBB), and 0.6% had complete heart block (CHB).
Abstract OBJECTIVE: The aim of this study was to examine the local myocardial segments in hypertrophic cardiomyopathy (HCM) by MRI T1 and T2 mapping, and to investigate how tissue remodeling correlates with structural and functional remodeling in HCM. METHODS: 47 patients with HCM and 19 healthy volunteers were enrolled in this study. All subjects underwent cardiac MRI at 3.0 T. Native T1 and T2 values, end-diastolic wall thickness (EDTH), and percentage of systolic wall thickening (PSWT) were assessed in the left ventricular segments according to the American Heart Association model. Myocardial segments were...
Publication date: October 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 10, SupplementAuthor(s): C. Blakely, R. Hart, G. VanDam, L. Smith, M. Hazell, D. Campbell, P. Branscombe, H. Abdollah
Publication date: October 2019Source: Canadian Journal of Cardiology, Volume 35, Issue 10, SupplementAuthor(s): A. Zhu, H. Bews, D. Cheung, R. Nagalingam, I. Mittal, V. Goyal, C. Asselin, I. Kirkpatrick, M. Czubryt, D. Jassal
Atrial fibrillation (AF) has important clinical consequences in hypertrophic cardiomyopathy (HC). Safety and efficacy of the Cox-Maze IV procedure (when combined with ventricular septal myectomy) in patients with obstructive HC and paroxysmal AF is largely unresolved. Records of 395 consecutive HC patients (age 55 ± 13 years) who underwent septal myectomy for heart failure symptoms between 2004 and 2015 were reviewed. Sixty-two patients also had concomitant complete biatrial Cox-Maze IV for a history of symptomatic paroxysmal AF (3.0 ± 3.6 episodes) combined with myectomy comprise the study cohort.
Publication date: Available online 7 October 2019Source: Journal of Cardiology CasesAuthor(s): Genzou Takemura, Kenji Onoue, Takanori Arimoto, Tetsu Watanabe, Akiko Tsujimoto, Chihiro Takada, Hideshi Okada, Tomoya Nakano, Yasuhiro Sakaguchi, Nagisa Miyazaki, Takatomo Watanabe, Hiromitsu Kanamori, Shinji Ogura, Yoshihiko Saito, Takako Fujiwara, Hisayoshi Fujiwara, Yasuaki HottaAbstractWe encountered an unfamiliar finding during electron microscopic examination of an endomyocardial biopsy obtained from a 55-year-old woman suffering from heart failure due to dilated phase hypertrophic cardiomyopathy. Many cardiomyocytes conta...
Significant left-ventricular outflow tract obstruction (LVOTO) in hypertrophic cardiomyopathy (HCM) may result in symptoms and is associated with adverse outcomes. Although disopyramide can reduce resting gradients, nearly 30% of HCM patients do not respond. We sought to study the clinical and echocardiographic variables associated with disopyramide-induced LVOT-gradient reduction.
This study aims to investigate the risk factors of in-hospital postoperative atrial fibrillation (POAF) and the impact of POAF on the clinical outcome in hypertrophic cardiomyopathy (HCM) patients who underwent myectomy. METHODS: Data from a total of 494 obstructive HCM patients, who had undergone preoperative cardiac magnetic resonance (CMR) testing and who underwent myectomy at Fuwai Hospital from June 2011 to June 2016, were collected. RESULTS: Multivariate logistic regression analysis showed that old age (odds ratio [OR], 4.326; 95% confidence interval [CI], 2.248-8.325; p
Mutations in the cardiac thin filament (TF) have highly variable effects on the regulatory function of the cardiac sarcomere. Understanding the molecular-level dysfunction elicited by TF mutations is crucial to elucidate cardiac disease mechanisms. The hypertrophic cardiomyopathy–causing cardiac troponin T (cTnT) mutation Δ160Glu (Δ160E) is located in a putative “hinge” adjacent to an unstructured linker connecting domains TNT1 and TNT2. Currently, no high-resolution structure exists for this region, limiting significantly our ability to understand its role in myofilament activation and the mo...
Condition: Hypertrophic Cardiomyopathy Intervention: Sponsor: AHEPA University Hospital Recruiting