Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma

Life of patients with uveal melanoma (UM) is largely threatened by liver metastasis. Little is known about the drivers of liver organotropic metastasis in UM. The elevated activity of transcription of oncogene...

Source: Molecular Cancer - September 16, 2019 Category: Cancer & Oncology Authors: Jing Zhang, Shenglan Liu, Qianyun Ye and Jingxuan Pan Tags: Research Source Type: research