Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma

Life of patients with uveal melanoma (UM) is largely threatened by liver metastasis. Little is known about the drivers of liver organotropic metastasis in UM. The elevated activity of transcription of oncogene...
Source: Molecular Cancer - Category: Cancer & Oncology Authors: Tags: Research Source Type: research

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Publication date: Available online 16 October 2019Source: Diagnostic and Interventional ImagingAuthor(s): E.M. Weisberg, L.C. Chu, S. Park, A.L. Yuille, K.W. Kinzler, B. Vogelstein, E.K. Fishman
Source: Diagnostic and Interventional Imaging - Category: Radiology Source Type: research
Publication date: Available online 17 October 2019Source: European Journal of RadiologyAuthor(s): Said Pertuz, Antti Sassi, Kirsi Holli-Helenius, Joni Kamarainen, Irina Rinta-Kiikka, Anna-Leena Laaperi, Otso ArponenAbstractPurposeTo assess the association between breast cancer risk and mammographic parenchymal measures obtained using a fully-automated, publicly available software, OpenBreast.MethodsThis retrospective case-control study involved screening mammograms of asymptomatic women diagnosed with breast cancer between 2016 and 2017. The 114 cases were matched with corresponding healthy controls by birth and screening ...
Source: European Journal of Radiology - Category: Radiology Source Type: research
ConclusionsThese results suggest that compared with PI-RADS v2, PI-RADS v2.1 could be preferable for evaluating TZ lesions.
Source: European Journal of Radiology - Category: Radiology Source Type: research
Conclusion: Standardized evaluation of TIL levels may provide valuable prognostic information in a spectrum of different malignancies. PMID: 31621387 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
Authors: Wang Q, Huang T, Ji J, Wang H, Guo C, Sun X, Zheng K, Dong Z, Cao Y Abstract Aim: To investigate and validate predictive value of combination of pretreatment monocyte-to-lymphocyte ratio (MLR) and neutrophil-to-lymphocyte ratio (NLR) for disease free survival (DFS) and overall survival (OS) in nonmuscle invasive bladder cancer after transurethral resection. Materials &methods: Total 358 patients enrolled were assigned into three (MLR-NLR 0, 1 and 2) groups per the cut-off values of MLR and NLR. Results: Kaplan-Meier curves showed MLR, NLR and their combination were statistically associated with DFS (p
Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
CONCLUSIONS: Learning curve in RARC-iON has a significant impact on achievement of Trifecta. This tool combines accurate measurement of surgical proficiency with an independent predictive value in assessing 3-yr OS probabilities. PMID: 31619034 [PubMed - as supplied by publisher]
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
Authors: Albisinni S, Veccia A, Aoun F, Diamand R, Esperto F, Porpiglia F, Roumeguère T, De Nunzio C Abstract INTRODUCTION: Robotic assisted radical cystectomy (RARC) is gaining popularity worldwide, although its enthusiastic implementation is supported mainly by retrospective studies. Aim of this review is to compare the outcomes of RARC and open radical cystectomy (ORC) in the setting of randomized controlled trials (RCTs). EVIDENCE ACQUISITION: Three search engines (PubMed, Embase®, and Web of Science) were queried up to January 1, 2019. Studies selections followed The Preferred Reporting Items fo...
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
Authors: De Luca S, Fiori C, Bollito E, Garrou D, Aimar R, Cattaneo G, De Cillis S, Manfredi M, Tota D, Massa F, Passera R, Porpiglia F Abstract BACKGROUND: To evaluate if multiparametric magnetic resonance (mpMRI)- transrectal ultrasound (TRUS) fusion targeted biopsy (TBx) versus untargeted standard biopsy (SBx) may decrease the rate of pathological upgrading of Gleason score (GS) 3+4 prostate cancer (PCa) at radical prostatectomy (RP). We also evaluated the impact of percent pattern 4 and cribriform glands at biopsy in the risk of GS 3 + 4 = 7 upgrading. METHODS: 301 patients with GS 3+4 PCa on biopsy (159 SB...
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
Publication date: October 2019Source: Journal of Comparative Pathology, Volume 172Author(s): M. Mikiewicz, K. Paździor-Czapula, M. Gesek, V. Lemishevskyi, I. Otrocka-DomagałaSummaryOral cavity tumours and tumour-like lesions are common in dogs and cats, and their diagnosis and classification requires histopathological examination. The aim of this study was to analyse retrospectively oral cavity lesions in dogs and cats in order to evaluate the distribution of inflammatory, hyperplastic and neoplastic lesions manifested as tumours. A total of 486 oral cavity tumours and tumour-like lesions (340 canine; 146 feline), diagno...
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
Publication date: Available online 17 October 2019Source: Pathology - Research and PracticeAuthor(s): Jia Yang, Junjie Shangguan, Aydin Eresen, Yu Lia, Jian Wang, Zhuoli ZhangAbstractDespite significant advances over the past decades of research, pancreatic cancer (PC) continues to have the worst 5-year survival of any malignancy. Dendritic cells (DCs) are the most potent professional antigen-presenting cells and are involved in the induction and regulation of antitumor immune responses. DC-based immunotherapy has been used in clinical trials for PC. Although safety, efficacy, and immune activation were reported in patient...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
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