A global genotyping survey of < i > Strongyloides stercoralis < /i > and < i > Strongyloides fuelleborni < /i > using deep amplicon sequencing

We report several novel findings including uniqueS.stercoralis andS.fuelleborni genotypes, and the first identifications of a previously unknownS.fuelleborni infecting humans within Australia. We expand on an existingStrongyloides genotyping scheme to accommodateS.fuelleborni and these novel genotypes. In doing so, we compare our data to all 18S andcox1 sequences ofS.fuelleborni andS.stercoralis available in GenBank (to our knowledge), that overlap with the sequences generated using our approach. As this analysis represents more than 1,000 sequences collected from diverse hosts and locations, representing all inhabited continents, it allows a truly global understanding of the population genetic structure of theStrongyloides species infecting humans, non-human primates, and domestic dogs.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research